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Biodegradable Scaffolds生物可分解材料

Polymer Scaffolds for Tissue Engineering 生物可分解材料應用于組織工程

應用生命科學和工程學的原理與技術, 研究、開發Biodegradable Scaffolds生物可分解材料用于修復、維護、促進人體各種組織或器官損傷后的功能和形態生物替代物.

Tissue loss is one of the most common problems in human healthcare. Tissue Engineering has been defined as "The use of naturally occurring and/or synthetic materials in conjunction with cells to create biologic substitutes to serve as functional tissue replacements."
In the late 1980's researchers developed porous PGA polymer scaffolds that enabled scientists to grow thick (1 mm and greater) layers of tissue. Since then, a number of functional tissue equivalents have been grown in the laboratory including skin, cartilage, tendon, bone, blood vessels, bowel, bladder and liver. Scaffolds fabricated from PGA have proven useful for growing three-dimensional tissue equivalents in vitro. Small-diameter fibers of PGA or PLA are randomly entangled to form a strong, flexible and porous three-dimensional matrix.
The scaffold allows cells to attach and grow in a three dimensional space while nutrient flow is maintained throughout the matrix.
Non-aligned scaffolds
Non-aligned scaffolds are fabricated from spun fibers using a non-woven textile process and resemble felt. Further modifications of the basic scaffold material can be conducted in the laboratory to enhance cell attachment and growth or to modify the physical properties and resorption rate of the non-aligned scaffold. The scaffolds are supplied non-sterile. Custom scaffolds made from polylactide (PLLA), PGA/PLLA copolymers and other synthetic resorbable polymers are available upon request.

Tissue loss is one of the most common problems in human healthcare. Tissue Engineering has been defined as "The use of naturally occurring and/or synthetic materials in conjunction with cells to create biologic substitutes to serve as functional tissue replacements."
In the late 1980's researchers developed porous PGA polymer scaffolds that enabled scientists to grow thick (1 mm and greater) layers of tissue. Since then, a number of functional tissue equivalents have been grown in the laboratory including skin, cartilage, tendon, bone, blood vessels, bowel, bladder and liver. Scaffolds fabricated from PGA have proven useful for growing three-dimensional tissue equivalents in vitro. Small-diameter fibers of PGA or PLA are randomly entangled to form a strong, flexible and porous three-dimensional matrix.
The scaffold allows cells to attach and grow in a three dimensional space while nutrient flow is maintained throughout the matrix.
Non-aligned scaffolds
Non-aligned scaffolds are fabricated from spun fibers using a non-woven textile process and resemble felt. Further modifications of the basic scaffold material can be conducted in the laboratory to enhance cell attachment and growth or to modify the physical properties and resorption rate of the non-aligned scaffold. The scaffolds are supplied non-sterile. Custom scaffolds made from polylactide (PLLA), PGA/PLLA copolymers and other synthetic resorbable polymers are available upon request.