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Human Growth Factors & Cytokines
Recombinant Human TRAIL/Apo2L


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Synonyms :
TNF-related apoptosis-inducing Ligand, TNFSF10, Apo2 Ligand, TL2
Description :
TRAIL/Apo2L is a cytotoxic protein, which activates rapid apoptosis in tumor cells, but not in normal cells. TRAIL induced apoptosis is achieved through binding to two death-signaling receptors, DR4 and DR5. These receptors belong to the TNFR superfamily of transmembrane proteins and contain a cytoplasmic "death domain", which activates the cells apoptotic machinery. Recombinant human soluble TRAIL/Apo2L is a 168 amino acid polypeptide (19.6 kDa), consisting of the TNF homologous portion of the extracellular domain of the full length TRAIL/Apo2L protein.
Catalog #:
310-04
Source :
E.coli
Purity :
Greater than 98% by SDS-PAGE gel and HPLC analysis.
Endotoxin Level :
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Biological Activity :
Assay#1:Determined by its ability to induce apoptotic cell death in TRAIL-sensitive U343MG cells. The expected ED50 for this effect is 1.0-3.0 ng/ml. 

Assay#2:Measured by its ability to induce apoptosis in LN-18 cells (human glioblastoma cells). The expected ED50 for this effect is 0.8 - 2.0 ng/ml.
Selected References :
Selected List of References Citing This PeproTech Product
AA Sequence :
MRERGPQRVA AHITGTRGRS NTLSSPNSKN EKALGRKINS WESSRSGHSF LSNLHLRNGE LVIHEKGFYY IYSQTYFRFQ EEIKENTKND KQMVQYIYKY TSYPDPILLM KSARNSCWSK DAEYGLYSIY QGGIFELKEN DRIFVSVTNE HLIDMDHEAS FFGAFLVG 
PubMed Link :
TRAIL+AND+TNF
Country of Origin :
USA
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Size A
10μg
$80?
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Size B
50μg
$195?
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Size C
1mg
$1500?
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Special Sizes: 
Many products can be ordered in custom sizes. Please click here to contact Peprotech with your request.
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Usage:
For Research Use Only. Not for use in diagnostic or therapeutic procedures. 

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