EIF4EBP1 (phospho S111) polyclonal antibody
產品名稱： EIF4EBP1 (phospho S111) polyclonal antibody
英文名稱： EIF4EBP1 (phospho S111) polyclonal antibody
產品編號： PAB8146
產品價格： null
產品產地： 臺灣
品牌商標： Abnova
更新時間： null
使用范圍：
亞諾法生技股份有限公司（Abnova)
- 聯系人 :
- 地址 : 臺灣臺北市內湖區洲子街 108 號 9 樓
- 郵編 : 11493
- 所在區域 : 臺灣
- 電話 : +886-920**1152 點擊查看
- 傳真 : 點擊查看
- 郵箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic phosphopeptide of EIF4EBP1.
- Immunogen:
- Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S111 of human EIF4EBP1.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Peptide affinity purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Dot Blot (1:500)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- 4E-binding protein 1: a key molecular "funnel factor" in human cancer with clinical implications.
Armengol G, Rojo F, Castellvi J, Iglesias C, Cuatrecasas M, Pons B, Baselga J, Ramon y Cajal S.Cancer Res. 2007 Aug 15;67(16):7551-5.
- 2.
- PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex.
Fonseca BD, Smith EM, Lee VH, MacKintosh C, Proud CG.J Biol Chem. 2007 Aug 24;282(34):24514-24. Epub 2007 Jun 29.
- Entrez GeneID:
- 1978
- Protein Accession#:
- NP_004086
- Gene Name:
- EIF4EBP1
- Gene Alias:
- 4E-BP1,4EBP1,BP-1,MGC4316,PHAS-I
- Gene Description:
- eukaryotic translation initiation factor 4E binding protein 1
- Omim ID:
- 602223
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq
- Other Designations:
- eIF4E-binding protein 1,phosphorylated heat- and acid-stable protein regulated by insulin 1
- Interactome
