英文名稱
Anti-ATF6 Polyclonal Antibody
別名
ACHM7;ATF6A
應用
WB
稀釋比例
WB 1:500-2000.
交叉反應
Human Mouse Rat
蛋白分子量
75kDa
Gene ID
22926
保存
Store at -20°C. Avoid freeze / thaw cycles.
儲存液
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
純化方法
Affinity purification
亞型
IgG
免疫原
Recombinant protein of human ATF6
性狀
液體
Public Immunogen Range
Recombinant protein of human ATF6
Subcellular Locations
Endoplasmic reticulum membrane Nucleus Single-pass type II membrane protein
Swiss Prot
P18850
克隆類型
Polyclonal Antibody
背景資料
This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis.