小鼠 白細(xì)胞表面抗原T細(xì)胞表面抗原20 全長(zhǎng) 蛋白 (重組表達(dá)病毒蛋白納米顆粒)
產(chǎn)品名稱： 小鼠 白細(xì)胞表面抗原T細(xì)胞表面抗原20 全長(zhǎng) 蛋白 (重組表達(dá)病毒蛋白納米顆粒)
英文名稱： Mouse CD20 Full Length Protein (VLP)
產(chǎn)品編號(hào)： CD0-M52P4
產(chǎn)品價(jià)格： 10500
產(chǎn)品產(chǎn)地： 中國(guó)
品牌商標(biāo)： 北京百普賽斯生物科技股份有限公司
更新時(shí)間： 2025-09-19T18:06:11
使用范圍： null
| 規(guī)格 | 價(jià)格 |
| 100ug |
- 聯(lián)系人 : 團(tuán)子
- 地址 : 北京經(jīng)濟(jì)技術(shù)開發(fā)區(qū)宏達(dá)北路8號(hào)5號(hào)樓4層
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- 所在區(qū)域 : 北京
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B-lymphocyte antigen CD20 is also known as B-lymphocyte surface antigen B1, Leukocyte surface antigen Leu-16, Membrane-spanning 4-domains subfamily A member 1 and MS4A1, is an activated-glycosylated phosphoprotein expressed on the surface of all B-cells beginning at the pro-B phase (CD45R+, CD117+) and progressively increasing in concentration until maturity. CD20 is expressed on all stages of B cell development except the first and last; it is present from late pro-B cells through memory cells, but not on either early pro-B cells or plasma blasts and plasma cells. It is found on B-cell lymphomas, hairy cell leukemia, B-cell chronic lymphocytic leukemia, and melanoma cancer stem cells. The protein has no known natural ligand and its function is to enable optimal B-cell immune response, specifically against T-independent antigens. It is suspected that it acts as a calcium channel in the cell membrane. CD20 / MS4A1 is the target of the monoclonal antibodies (mAb) rituximab, Ibritumomab tiuxetan, and tositumomab, which are all active agents in the treatment of all B cell lymphomas and leukemias. Defects in CD20 / MS4A1 are the cause of immunodeficiency common variable type 5 (CVID5); also called antibody deficiency due to CD20 defect. CVID5 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen.