RCAN2 Antibody
產(chǎn)品名稱： RCAN2 Antibody
英文名稱： RCAN2 Antibody
產(chǎn)品編號(hào)： 254029
產(chǎn)品價(jià)格： null
產(chǎn)品產(chǎn)地： 美國(guó)
品牌商標(biāo)： Abbiotec
更新時(shí)間： null
使用范圍： E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:00-1:500
深圳市豪地華拓生物科技有限公司
- 聯(lián)系人 :
- 地址 : 深圳市南山創(chuàng)業(yè)路中興城5棟518
- 郵編 : 518054
- 所在區(qū)域 : 廣東
- 電話 : 132****4656 點(diǎn)擊查看
- 傳真 : 點(diǎn)擊查看
- 郵箱 : order@otwobiotech.com
Regulator of calcineurin 2 (RCAN2), also known as ZAKI4 and DSCR1L1, is expressed as two isoforms differing at their N-terminus. The longer of the two (isoform 1) is expressed exclusively in the brain, while isoform 2 is ubiquitously expressed, with highest expression in brain, heart, and muscle. Both isoforms bind to the catalytic subunit of calcineurin, a Ca++-dependent protein phosphatase involved in several neuronal functions, though their C-terminal region and inhibit calcineurin’s activity. Unlike isoform 1 of RCAN2, the expression of the second isoform is not induced by the thyroid hormone T3. RCAN2 is a member of a family of three endogenous calcineurin regulators that are located near the minimal supernumerary fragment of chromosome 21 in individuals with Down syndrome, suggesting that they play a role in this syndrome. Multiple isoforms of RCAN2 are known to exist.