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Voltage gated channels are tetrameters composed of four alpha-subunits arranged around a central pore. Each alpha subunit
consists of six transmembrane segments with
cytoplasmic NH2 and COHO-termini. Members of the KV1-
KV4 subfamilies generate functional K+ channels in a
homotetrameric configuration. The KV2 subfamily consists of
KV2.1 and KV2.2, and both have very similar properties.
Members of the KV2 subfamily are widely expressed in
neuronal tissues. They have also been reported in neurons in
the dorsal root ganglia (3-5).