LIG4 (Human) Recombinant Protein (Q01)
產(chǎn)品名稱: LIG4 (Human) Recombinant Protein (Q01)
英文名稱: LIG4 (Human) Recombinant Protein (Q01)
產(chǎn)品編號(hào): H00003981-Q01
產(chǎn)品價(jià)格: 0
產(chǎn)品產(chǎn)地: 臺(tái)灣
品牌商標(biāo): Abnova
更新時(shí)間: null
使用范圍: null
亞諾法生技股份有限公司(Abnova)
- 聯(lián)系人 :
- 地址 : 臺(tái)灣臺(tái)北市內(nèi)湖區(qū)洲子街 108 號(hào) 9 樓
- 郵編 : 11493
- 所在區(qū)域 : 臺(tái)灣
- 電話 : +886-920**1152 點(diǎn)擊查看
- 傳真 : 點(diǎn)擊查看
- 郵箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Human LIG4 partial ORF ( AAH37491, 802 a.a. - 911 a.a.) recombinant protein with GST-tag at N-terminal.
- Sequence:
- RYSWDCSPLSMFRRHTVYLDSYAVINDLSTKNEGTRLAIKALELRFHGAKVVSCLAEGVSHVIIGEDHSRVADFKAFRRTFKRKFKILKESWVTDSIDKCELQEENQYLI
- Theoretical MW (kDa):
- 37.73
- Preparation Method:
- in vitro wheat germ expression system
- Purification:
- Glutathione Sepharose 4 Fast Flow
- Storage Buffer:
- 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
- Storage Instruction:
- Store at -80°C. Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- 12.5% SDS-PAGE Stained with Coomassie Blue.

- Note:
- Best use within three months from the date of receipt of this protein.
- MSDS:
Download
- Application Image
- Enzyme-linked Immunoabsorbent Assay
- Western Blot (Recombinant protein)
- Antibody Production
- Protein Array
- Entrez GeneID:
- 3981
- GeneBank Accession#:
- BC037491
- Protein Accession#:
- AAH37491
- Gene Name:
- LIG4
- Gene Alias:
- -
- Gene Description:
- ligase IV, DNA, ATP-dependent
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq
- Other Designations:
- DNA joinase,DNA ligase IV,DNA repair enzyme,polydeoxyribonucleotide synthase [ATP] 4,polynucleotide ligase,sealase
- Gene Pathway
- Related Disease
- Adenocarcinoma
- Ascariasis
- Asthma
- Asthma
- Ataxia telangiectasia
- Brain Neoplasms
- Breast cancer
- Breast Neoplasms
- Carcinoma, Basal Cell
- Carcinoma, Non-Small-Cell Lung
- Carcinoma, Papillary
- Carcinoma, Squamous Cell
- Colorectal Neoplasms
- DNA Damage
- Esophageal Neoplasms
- Genetic Predisposition to Disease
- Genomic Instability
- Glioma
- Head and Neck Neoplasms
