中文名稱 鈣/鈣調蛋白依賴性蛋白激酶4重組兔單克隆抗體  別????名 Brain Ca(2+) calmodulin dependent protein kinase type 4; Brain Ca(2+) calmodulin dependent protein kinase type IV; Calcium / calmodulin dependent protein kinase type 4 catalytic chain; Calcium / calmodulin dependent protein kinase type IV catalytic chain; Calcium/calmodulin dependent protein kinase IV; Calcium/calmodulin dependent protein kinase type IV; CAM kinase 4; CAM kinase GR; CAM kinase IV; CaMK 4; CAMK GR; CaMK IV; CaMK4; CaMKGR; MGC36771.??  研究領域 細胞生物??神經生物學??信號轉導??轉錄調節因子??激酶和磷酸酶??表觀遺傳學??  抗體來源 Rabbit  克隆類型 Monoclonal  克?隆?號 3F11  交叉反應 (predicted: Human,?Mouse,?Rat,?)  產品應用 WB=1:500-2000?IHC-P=1:50-200?ICC=1:50-200?IF=1:50-200?（石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.  分?子?量 55kDa  細胞定位 細胞核?  性????狀 Liquid  濃????度 1mg/ml  免?疫?原 Recombinant protein corresponding to the C-terminus of human CAMK4:?  亞????型 IgG  純化方法 affinity purified by Protein A  儲?存?液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.  保存條件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.  PubMed PubMed  產品介紹 Ca2+/calmodulin dependent protein kinase type IV (CAMKIV) belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells.  Function: Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consodilation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen re