GRM1 polyclonal antibody
產(chǎn)品名稱： GRM1 polyclonal antibody
英文名稱： GRM1 polyclonal antibody
產(chǎn)品編號(hào)： PAB1119
產(chǎn)品價(jià)格： null
產(chǎn)品產(chǎn)地： 臺(tái)灣
品牌商標(biāo)： Abnova
更新時(shí)間： null
使用范圍：
亞諾法生技股份有限公司（Abnova)
- 聯(lián)系人 :
- 地址 : 臺(tái)灣臺(tái)北市內(nèi)湖區(qū)洲子街 108 號(hào) 9 樓
- 郵編 : 11493
- 所在區(qū)域 : 臺(tái)灣
- 電話 : +886-920**1152 點(diǎn)擊查看
- 傳真 : 點(diǎn)擊查看
- 郵箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of GRM1.
- Immunogen:
- A synthetic peptide corresponding to the human GRM1.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse, Rat
- Form:
- Liquid
- Storage Buffer:
- In PBS (0.02% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (1:500-1:1000)
Immunohistochemistry (1:100-1:500)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Applications
- Western Blot (Tissue lysate)
- Western blot detection of GRM1. In 20 ug of human brain tissue lysate with GRM1 polyclonal antibody (Cat # PAB1119) at 1 : 1000 dilution followed by AP - conjugated secondary at 1 : 5000 dilution.
- Immunofluorescence
- Immunofluorescence labeling for GRM1 in rat brain (cingulate cortex). GRM1 detection was done using anti-rabbit Cy3 conjugated antibodies (red color). DAPI was used to counterstain cell nuclei (blue color). Working dilution of GRM1 polyclonal antibody (Cat # PAB1119) is 1 : 100-1 : 500.
- Entrez GeneID:
- 2911
- Gene Name:
- GRM1
- Gene Alias:
- GPRC1A,GRM1A,MGLUR1,MGLUR1A,mGlu1
- Gene Description:
- glutamate receptor, metabotropic 1
- Omim ID:
- 604473
- Gene Ontology:
- Hyperlink
- Gene Summary:
- L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. The canonical alpha isoform of the metabotropic glutamate receptor 1 gene is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. Alternative splicing results in multiple transcript variants encoding distinct isoforms; some of which may have distinct functions. [provided by RefSeq
- Other Designations:
- OTTHUMP00000017365