Background:? CREM is a a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is derived from a multiexonic gene that encodes both activators and antagonists of cAMP-inducible transcription by differential splicing. Splice variants with antagonistic function lack 2 glutamine-rich domains and block cAMP-induced transcription, whereas an isoform that includes these glutamine-rich domains is a transcriptional activator.

Description: Rabbit polyclonal to CREM

Immunogen: KLH conjugated synthetic peptide derived from CREM

Specificity: ?·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:? ·Western blotting: 1/500-1000. Predicted Mol wt: 34 kDa;

·Immunohistochemistry (Frozen/paraffin tissue section): 1/100-500;

·Immunocytochemistry: 1/200-500;

·ELISA: 1/500;

· Optimal working dilutions must be determined by the end user.