Anti-PPP4C
產品名稱： Anti-PPP4C
英文名稱：
產品編號： 200228
產品價格： null
產品產地： 成都正能生物
品牌商標： Zen BioScience
更新時間： null
使用范圍： WB,IHC,ICC
- 聯系人 :
- 地址 : 中國成都高新區科園南路愛斯特大廈
- 郵編 : 610200
- 所在區域 : 四川
- 電話 : 180****2350 點擊查看
- 傳真 : 點擊查看
- 郵箱 : sales@zen-bioscience.com
Size??100ug
Cat code??200228
Species Cross-reactivity??H
Key Application??WB,IHC,ICC
Host??Mouse
Antibody type??Monoclonal antibody
Purified method??Affinity purified
Isotype??IgG2a
Molecular Weight??34kDa
Sensitivity??This antibody detects endogenous levels Protein Phosphatase 4C and does not cross-react with related proteins.
Immunogen??Purified recombinant human Protein Phosphatase 4C protein fragments expressed in E.coli.
UniProt Number??P60510
GeneBank ID??NM_002720
Subcellular location??Cytoplasm. Nucleus
Formulation??Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50%,glycerol
Altername??PP4; PPX; PP4C; PPH3; PPP4;Protein Phosphatase 4C
Gene_symbol??PP4; PPX; PP4C; PPH3; PPP4
Summary??Protein phosphatase 4C may be involved in microtubule organization. It binds 1 iron ion and 1 manganese ion per subunit. PP4 consists of a catalytic subunit PPP4C and a regulatory subunit. PPP4R1 and belongs to the PPP phosphatase family, PP X subfamily.
UniPort summary Function??Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity)
Application Images :??
Western blot detection of Protein Phosphatase 4C antibody in Hela,293&Jurkat cell lysates using Protein Phosphatase 4C antibody (1:1000 diluted). Predicted band size: 34KDa Observed band size: 34KDa
Immunocytochemistry of HeLa cells using anti- Protein Phosphatase 4C antibody diluted 1:200.
IHC of paraffin-embedded human breast cancer using anti-Protein Phosphatase 4C diluted 1/500-1/1000.
