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英文名稱 14-3-3?中文名稱 14-3-3蛋白重組兔單克隆抗體?別? ? 名 14 3 3 alpha; 14 3 3 protein beta/alpha; 14-3-3 protein beta/alpha; 1433B_HUMAN; Brain protein 14 3 3 beta isoform; GW128; HS 1; KCIP-1; KCIP1; N-terminally processed; Protein 1054; Protein kinase C inhibitor protein 1; YWHAA; YWHAB.? ?研究領域 細胞生物? 神經生物學? 信號轉導? 細胞凋亡? ?抗體來源 Rabbit?克隆類型 Monoclonal?克 隆 號 9C4?交叉反應 (predicted: Human, Mouse, Rat, )?產品應用 WB=1:500-2000?not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.?分 子 量 28/19kDa?細胞定位 細胞漿 細胞膜??性? ? 狀 Liquid?濃? ? 度 1mg/ml?免 疫 原 Recombinant human 14-3-3 protein:??亞? ? 型 IgG?純化方法 affinity purified by Protein A?儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.?保存條件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.?PubMed PubMed?產品介紹 14-3-3 are activates tyrosine and tryptophan hydroxylases in the presence of Ca (2+)/calmodulin-dependent protein kinase II, and strongly activates protein kinase C. Is probably a multifunctional regulator of the cell signaling processes mediated by both kinases. Activates the ADP-ribosyltransferase (exoS) activity of bacterial origin. 14-3-3 proteins are localized in neurons, and are axonally transported to the nerve terminals. They may be also present, at lower levels, in various other eukaryotic tissues. It belongs to the 14-3-3 family.
Function:Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis.
Subcellular Location:Cytoplasm. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Post-translational modifications:The alpha, brain-specific form differs from the beta form in being phosphorylated.Isoform Short contains a N-acetylmethionine at pos