Size??100ul
Cat code??220027
Species Cross-reactivity??H,Mk
Key Application??WB
Host??Mouse
Clone Number??2C12-D10-F1
Antibody type??Monoclonal antibody
Purified method??Affinity purified
Isotype??IgG1
Molecular Weight??67.8kDa
Sensitivity??The antibody detects endogenous level of total MSN protein.
Immunogen??Purified recombinant fragment of human MSN expressed in E. Coli.
UniProt Number??P26038
GeneBank ID??NM_002444.2
Subcellular location??Cell membrane. Cytoplasm > cytoskeleton. Apical cell membrane. Cell projection > microvillus membrane. Phosphorylated form is enriched in microvilli-like structures at apical membrane (By similarity). Increased cell membrane localization of both phosphorylated and non-phosphorylated forms seen after thrombin treatment.
Formulation??Purified antibody in PBS with 0.05% sodium azide and 0.5% protein stabilizer
Altername??Membrane organizing extension spike protein ; Membrane-organizing extension spike protein ; MOES_HUMAN ; Moesin ; Moesin/anaplastic lymphoma kinase fusion protein ; Msn ; MSN/ALK fusion ;
Gene_symbol??
Summary??Moesin (for membrane-organizing extension spike protein) is a member of the ERM family which includes ezrin and radixin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. Moesin is localized to filopodia and other membranous protrusions that are important for cell-cell recognition and signaling and for cell movement. [provided by RefSeq, Jul 2008]
UniPort summary  Function??Probably involved in connections of major cytoskeletal structures to the plasma membrane. May inhibit herpes simplex virus 1 infection at an early stage.
Application Images :??
Western blot detection of MSN antibody in COS7, Jurkat, HaCat and Hela cell lysates using MSN antibody(dilution 1:500).Predicted band size:67.8KDa.Observed band size:67.8KDa.