Anti-Orai1 Rabbit Polyclonal Antibody (Orai1-L1)-抗體-抗體-生物在線
武漢紐斯特生物技術有限公司
Anti-Orai1 Rabbit Polyclonal Antibody (Orai1-L1)

Anti-Orai1 Rabbit Polyclonal Antibody (Orai1-L1)

商家詢價

產品名稱： Anti-Orai1 Rabbit Polyclonal Antibody (Orai1-L1)

英文名稱： Anti-Orai1 Rabbit Polyclonal Antibody (Orai1-L1)

產品編號： 21001

產品價格： null

產品產地： 美國

品牌商標： NewEastbio

更新時間： null

使用范圍： ELISA, WB, IHC

武漢紐斯特生物技術有限公司
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  • 地址 : 武漢市東湖新技術開發區光谷生物城B3-3棟2-3樓
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  • 所在區域 : 湖北
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Orai1-L1 [21001]
[100 μL]		 ?

Catalog Number:??21001
Gene Symbol:??Orai1
Description: ??Anti-Orai1 Rabbit Polyclonal Antibody (Orai1-L1)
Background: ??Store-operated calcium channels (SOCs) play essential functions in various physiological processes. Orai1 (also named CRACM1) is a critical molecular component of SOCs. Orai1 protein is a ~35 kDa plasma membrane protein with 4 transmembrane domains. Human patients with a severe combinaed immunodeficiency (SCID) syndrome possess point mutations in Orai1 gene.
Immunogen: ??A peptide from the extracellular loop 1 region of human Orai1
Applications: ??ELISA, WB, IHC
Recommended Dilutions: ??
ELISA:??????1:1000-1:5000,
WB:??????????1:1000-1:2000,
IHC:??????????1:100-1:200
Concentration: ??
Host: ??Rabbit
Format: ??Liquid
Clonality: ??Polyclonal
Isotype: ??IgG
Purity: ??Immunogen affinity purified
Storage buffer:
Preservative:??0.01% sodium azide
Constituents:?? 50mM NaHCO3-Glycine, 0.15M NaCl, pH7.4
Species Reactivity:??Orai1-L1 antibody recognizes Orai1 from human and mouse. It may also recognize Orai2 and Orai3.
Storage Conditions:??Store at -20°C. Avoid freeze / thaw cycles
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Western blot:??
Western blot analysis of Orai1 protein. Human Orai1 plasmid DNA was transiently transfected into HEK-293 cells. Whole-cell lysate was used for western blot in the absence (lane 1) or presence (lane 2) of antigen peptide.
Immunohistochemistry ??
Immunohistochemistry of endogenous Orai1 in NIH3T3 cells showing the plasma membrane staining.
Publications:
1.??Generation and Characterization of Fully Human Monoclonal Antibodies Against Human Orai1 for Autoimmune Disease
????J Pharmacol Exp Ther. 2013 May;345(2):225-38
2.??Influence of Orai1 intervention on mouse airway epithelium reactions in vivo and in vitro
????Ann Allergy Asthma Immunol. 2012 Feb;108(2):103-12
3.??2-Aminoethoxydiphenyl borate administration into the nostril alleviates murine allergic rhinitis
????Am J Otolaryngol. 2011 Jul-Aug;32(4):318-28
4.??Up-regulation of Orai1 in murine allergic rhinitis
????Histochem Cell Biol. 2010 Jul;134(1):93-102
5.??Orai1 and STIM1 are critical for breast tumor cell migration and metastasis
????Cancer Cell. 2009 Feb 3;15(2):124-34
6.??Amelioration of Muc5b mucin hypersecretion is enhanced by IL-33 after 2-APB administration in a murine model of allergic rhinitis
????Biotech Histochem. 2014 May;89(4):273-86

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