Amyloid β-Protein (1-42)
產(chǎn)品名稱： Amyloid β-Protein (1-42)
英文名稱： Amyloid β-Protein (1-42)
產(chǎn)品編號： HD130001
產(chǎn)品價格： null
產(chǎn)品產(chǎn)地： 武漢
品牌商標： 昊德
更新時間： null
使用范圍：
- 聯(lián)系人 :
- 地址 : 武漢市江夏區(qū)譚湖一路光谷8號工坊
- 郵編 :
- 所在區(qū)域 : 湖北
- 電話 : 189****5746 點擊查看
- 傳真 : 點擊查看
- 郵箱 : dingjimin001@moonbiochem.com
Amyloid β-Protein (1-42)
CompanySerial Number：HD130001
ProductName：Amyloid β-Protein (1-42)
Synonym：
CASNo.：107761-42-2
Sequence(three-letter)：H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH
Sequence(one-letter)： DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA-OH
ConstitutionalFormula：
MolecularFormula： C203H311N55O60S
MolecularWeight：4514.1
References： J.Kanget al., Nature, 325, 733 (1987)
D.Goldgaber et al., Science, 235, 877 (1987)
J.Murrell et al., Science, 254, 97 (1991)
C.J.Pike et al., Neuroscience, 63, 517 (1994)
M.Pitschke et al., Nat. Med., 4, 832 (1998)
G.Bitan et al., Proc. Natl. Acad. Sci. USA, 100, 330 (2003)
W.B.Stine et al., J. Biol. Chem., 278, 11612 (2003)
D.A.Butterfield and D.Boyd-Kimball, Biochim. Biophys. Acta, 1703, 149 (2005)
S.Gandy, J. Clin. Invest., 115, 1121 (2007)
D.M.Walsh and D.J.Selkoe, J. Neurochem., 101, 1172 (2007)
A.Jan et al., Nat. Protoc., 5, 1186 (2010)
Illustration：This42-residue fragment of amyloid β-protein has been found to be a majorconstituent of the senile plaques formed in the brains of patients withAlzheimer's disease and late Down's syndrome. Aβ 1-42 readily forms neurotoxicoligomers at physiological pH. The peptide has been used to detect amyloidβ-protein multimers in the cerebrospinal fluid of Alzheimer's disease patientsthrough fluorescence correlation spectroscopy. For detailed descriptions of thepreparation of Aβ 1-42 monomers and protofibrils please see the paper of Jan,Hartley, and Lashuel.
ConditionOf Storage: -20± 5 °C