Recombinant  Human R-Spondin-2
Catalog  Number:
120-43
Synonyms:
Roof  plate-specific, spondin-2, RSPO2
Description:
The  R-Spondin (Rspo) proteins belong to the Rspo family of Wnt modulators.  Currently, the family consists of four structurally related secreted ligands  (Rspo 1-4), all containing furin-like and thrombospondin structural domains. The  Rspo proteins can interact with the Frizzled/LRP6 receptor complex in a manner  that causes the stabilization and resulting accumulation of the intracellular  signaling protein, β-catenin. This activity effectively activates and increases  the subsequent nuclear signaling of β-catenin. R-Spondin can also bind to the  previously discovered G-protein coupled receptors, LGR-4 and LGR-5.  Rspo/β-catenin signaling can act as an inducer of the transformed phenotype, and  can also regulate the proliferation and differentiation of certain stem cell  populations.? Recombinant human R-Spondin-2 is a 24.4 kDa protein consisting of  212 amino acid residues.? Due to glycosylation, R-Spondin-2 migrates at an  apparent molecular weight of approximately 30.0 kDa by SDS PAGE analysis under  reducing conditions.
AA  Sequence:
ASYVSNPICK GCLSCSKDNG CSRCQQKLFF FLRREGMRQY GECLHSCPSG  YYGHRAPDMN RCARCRIENC DSCFSKDFCT KCKVGFYLHR GRCFDECPDG FAPLEETMEC VEGCEVGHWS  EWGTCSRNNR TCGFKWGLET RTRQIVKKPV KDTILCPTIA ESRRCKMTMR HCPGGKRTPK AKEKRNKKKK  RKLIERAQEQ HSVFLATDRA NQ
Source:
CHO  cells
Purity:
Greater  than 95% by SDS-PAGE gel and HPLC analyses.
Biological  Activity:
R-Spondin-2  enhances BMP-2 mediated differentiation of MC3T3-E1 cells.
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Research  Interests:
 
 
 
 
Cancer
 
 
Proliferation
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Country  of Origin:
USA
Research  Use Only. Not for use in diagnostic or therapeutic procedures.