英文名稱 14-3-3 sigma (2E12) 
中文名稱 14-3-3 sigm重組兔單克隆抗體 
別????名 14 3 3 protein sigma; 14-3-3 protein sigma; 1433S_HUMAN; Epithelial cell marker protein 1; Er; HME 1; HME1; MGC143283; Mkrn3; Mme1; OTTHUMP00000004242; RP23 137L22.11; SFN; SFN protein; Stratifin; YWHAS.?? 
研究領域 細胞生物??染色質和核信號??神經生物學??信號轉導??干細胞??轉錄調節因子?? 
抗體來源 Rabbit 
克隆類型 Monoclonal 
克?隆?號 2E12 
交叉反應 (predicted: Human,?) 
產品應用 WB=1:500-1000?IHC-P=1:50-200?IHC-F=1:50-200?ICC=1:50-200?IF=1:50-200?（石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user. 
分?子?量 28kDa 
細胞定位 細胞核?細胞漿?分泌型蛋白? 
性????狀 Liquid 
濃????度 1mg/ml 
免?疫?原 recombinant human 14-3-3 sigma full length protein:? 
亞????型 IgG 
純化方法 affinity purified by Protein A 
儲?存?液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 
保存條件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. 
PubMed PubMed 
產品介紹 14-3-3 proteins regulate many cellular processes relevant to cancer biology, notably apoptosis, mitogenic signaling and cell-cycle checkpoints. Seven isoforms, denoted 14-3-3 b, g, e, z, h, q and s, comprise this family of signaling intermediates. 14-3-3 s, also known as SFN, stratifin, HME1 or YWHAS, is a secreted adaptor protein that is involved in regulating both general and specific signaling pathways. Expressed predominately in stratified squamous keratinising epithelium, 14-3-3 s is able to bind and modify the activity of a large number of proteins, such as KRT17 (Keratin 17), through recognition of a phosphothreonine or phosphoserine motif. When bound to Keratin 17, for example, 14-3-3 s acts to stimulate the Akt/mTOR signaling pathway by upregulating protein synthesis and cell growth. 14-3-3 s also functions to positively mediate IGF-I-induced cell cycle progression and can bind to a variety of translation initiation factors, thus controlling mitotic translation. In response to tumor growth, 14-3-3 s positively regulates the tumor suppressor p53 and increases the rate of p53-regulated inhibit