[KO Validated] FADD Rabbit pAb (APR24177N)
產(chǎn)品名稱： [KO Validated] FADD Rabbit pAb (APR24177N)
英文名稱： [KO Validated] FADD Rabbit pAb (APR24177N)
產(chǎn)品編號(hào)： APR24177N
產(chǎn)品價(jià)格： null
產(chǎn)品產(chǎn)地： 美國(guó)
品牌商標(biāo)： Leading Biology
更新時(shí)間： null
使用范圍：
生物谷
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分子量：Calculated MW: 23kDa Observed MW: 28kDa 稀釋方法：WB 1:500 - 1:2000 總結(jié)：The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.