MonoMethyl-UHRF1-K385 Rabbit pAb (AMR00696N)
產(chǎn)品名稱： MonoMethyl-UHRF1-K385 Rabbit pAb (AMR00696N)
英文名稱： MonoMethyl-UHRF1-K385 Rabbit pAb (AMR00696N)
產(chǎn)品編號： AMR00696N
產(chǎn)品價格： null
產(chǎn)品產(chǎn)地： 美國
品牌商標： Leading Biology
更新時間： null
使用范圍：
分子量：Calculated MW: 89kDa/91kDa Observed MW: 91kDa 細胞定位：Nucleus 稀釋方法：DB 1:500 - 1:2000 WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 總結(jié)：This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12.