酪氨酸激酶A/B/C重組兔單克隆抗體
產品名稱： 酪氨酸激酶A/B/C重組兔單克隆抗體
英文名稱： Trk A + B + C
產品編號： YJ-52949
產品價格： null
產品產地： 上海
品牌商標： 雅吉
更新時間： null
使用范圍： WB, IF, ICC
上海雅吉生物科技有限公司
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?中文名稱?酪氨酸激酶A/B/C重組兔單克隆抗體?別? ? 名 TrkA/B/C; TrkA+B+C; Trk A; Trk B; Trk C; TrkB; TrkC; Tyrosine Receptor Kinase A; Tyrosine Receptor Kinase B; Tyrosine Receptor Kinase C.? ?研究領域 細胞生物? 免疫學? 神經生物學? 信號轉導? 細胞凋亡? ?抗體來源 Rabbit?克隆類型 Monoclonal?克 隆 號 5T6?交叉反應 (predicted: Human, Mouse, Rat, )?產品應用 WB=1:1000-5000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 IF=1:50-200 （石蠟切片需做抗原修復）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.?分 子 量 90kDa?細胞定位 細胞膜??性? ? 狀 Liquid?濃? ? 度 1mg/ml?免 疫 原 KLH conjugated synthetic peptide derived from human Trk A:??亞? ? 型 IgG?純化方法 affinity purified by Protein A?儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.?保存條件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.?PubMed PubMed?產品介紹 The Trk family of nerve growth factor receptors includes Trk A(also referfed to as Trk A gp140),Trk B and Trk C. The prototype member of this gene family, Trk A, encodes a 140 kDa cell surface receptor, gp140, the expression of which is restricted in vivo to neurons of the sensory spinal and cranial gangliaof neurocrest origin. Nerve growth factor (NGF) stimulates tyrosine phosphorylation of Trk gp 140 in neural cell lines and in embryonic dorsal root ganglia. By comparison, BDNF and to a lesser extent, NT-3, but not NGF, can induce tyrosine phophorylayion of Trk B gp 145. The third member of the Trk receptor family, Trk C incodes a 140 kDa protein, Trk C gp140, that is preferentially expressed in brain tissue and primarily functions as a receptor for NT-3.An additional component of the Trk receptor complex, NGFR p175, binds to neurotrophic factors with low affinity but is required for efficient signaling. NGFR p175 accelerates Trk activation and may recruit downstream dffector molecules to the ligand-bound receptor complex.?Function:Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differ
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