脂質(zhì)運(yùn)載蛋白-2 / NGAL肽(60-72)
產(chǎn)品名稱(chēng)： 脂質(zhì)運(yùn)載蛋白-2 / NGAL肽(60-72)
英文名稱(chēng)： 24p3 25 kDa alpha 2 microglobulin related subunit of MMP9 25 kDa alpha-2-microglobulin-related subunit of MMP-9 Alpha 2 microglobulin relate
產(chǎn)品編號(hào)： ab45738
產(chǎn)品價(jià)格： 0
產(chǎn)品產(chǎn)地： 英國(guó)
品牌商標(biāo)： abcam
更新時(shí)間： null
使用范圍： null
深圳市宇德立生物科技有限公司
- 聯(lián)系人 :
- 地址 : 深圳市寶安區(qū)西鄉(xiāng)寶民二路賢基大廈4E
- 郵編 :
- 所在區(qū)域 : 廣東
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- 性質(zhì)Synthetic
- 氨基酸序列
- 種屬Human
- 序列C-AILREDKDPQKMY
- 氨基酸60 to 72
技術(shù)指標(biāo)
Our?Abpromise guarantee?covers the use of?ab45738?in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
- 形式Liquid
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濃度100 μg 濃度為 1 mg/ml?
制備和貯存
- 穩(wěn)定性和存儲(chǔ)
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
常規(guī)信息
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別名
- 24p3
- 25 kDa alpha 2 microglobulin related subunit of MMP9
- 25 kDa alpha-2-microglobulin-related subunit of MMP-9
see all - 功能Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth.
- 組織特異性Expressed in bone marrow and in tissues that are prone to exposure to microorganism. High expression is found in bone marrow as well as in uterus, prostate, salivary gland, stomach, appendix, colon, trachea and lung. Not found in the small intestine or peripheral blood leukocytes.
- 序列相似性Belongs to the calycin superfamily. Lipocalin family.
- 細(xì)胞定位Secreted. Upon binding to the SLC22A17 (24p3R) receptor, it is internalized.