Anti-CASP8 Polyclonal Antibody
品牌：solarbio | 貨號：K001600P
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商品品牌：
規格
基本售價：
選擇規格
K001600P-50ul
solarbio
50ul
960.00元
K001600P-100ul
solarbio
100ul
1600.00元

英文名稱
Anti-CASP8 Polyclonal Antibody
別名
ALPS2B;CAP4;Casp-8;FLICE;MACH;MCH5
應用
WB IF
稀釋比例
WB 1:500-2000. IF 1:50-200.
交叉反應
Human Mouse
蛋白分子量
55kDa
Gene ID
841
保存
Store at -20°C. Avoid freeze / thaw cycles.
儲存液
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
純化方法
Affinity purification
亞型
IgG
免疫原
Recombinant protein of human CASP8
性狀
液體
Public Immunogen Range
Recombinant protein of human CASP8
Subcellular Locations
Cytoplasm
Swiss Prot
Q14790
克隆類型
Polyclonal Antibody
背景資料
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined.