BRAF (phospho T598) polyclonal antibody
產品名稱： BRAF (phospho T598) polyclonal antibody
英文名稱： BRAF (phospho T598) polyclonal antibody
產品編號： PAB8084
產品價格： null
產品產地： 臺灣
品牌商標： Abnova
更新時間： null
使用范圍：
亞諾法生技股份有限公司（Abnova)
- 聯系人 :
- 地址 : 臺灣臺北市內湖區洲子街 108 號 9 樓
- 郵編 : 11493
- 所在區域 : 臺灣
- 電話 : +886-920**1152 點擊查看
- 傳真 : 點擊查看
- 郵箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic phosphopeptide of BRAF.
- Immunogen:
- Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding T598 of human BRAF.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein A purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Dot Blot (1:500)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- BRAF kinase gene V599E mutation in growing melanocytic lesions.
Loewe R, Kittler H, Fischer G, Fae I, Wolff K, Petzelbauer P.J Invest Dermatol. 2004 Oct;123(4):733-6.
- 2.
- Alternative mutations of BRAF, RET and NTRK1 are associated with similar but distinct gene expression patterns in papillary thyroid cancer.
Frattini M, Ferrario C, Bressan P, Balestra D, De Cecco L, Mondellini P, Bongarzone I, Collini P, Gariboldi M, Pilotti S, Pierotti MA, Greco A.Oncogene. 2004 Sep 23;23(44):7436-40.
- 3.
- Calcium restriction allows cAMP activation of the B-Raf/ERK pathway, switching cells to a cAMP-dependent growth-stimulated phenotype.
Yamaguchi T, Wallace DP, Magenheimer BS, Hempson SJ, Grantham JJ, Calvet JP.J Biol Chem. 2004 Sep 24;279(39):40419-30. Epub 2004 Jul 19.
- Entrez GeneID:
- 673
- Protein Accession#:
- NP_004324;P15056
- Gene Name:
- BRAF
- Gene Alias:
- B-RAF1,BRAF1,FLJ95109,MGC126806,MGC138284,RAFB1
- Gene Description:
- v-raf murine sarcoma viral oncogene homolog B1
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome, a disease characterized by heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located on chromosome X, has been identified for this gene. [provided by RefSeq
- Other Designations:
- 94 kDa B-raf protein,B-Raf proto-oncogene serine/threonine-protein kinase (p94),Murine sarcoma viral (v-raf) oncogene homolog B1
- Gene Pathway
- Acute myeloid leukemia
- Bladder cancer
- Chemokine signaling pathway
- Chronic myeloid leukemia
- Colorectal cancer
- Endometrial cancer
- ErbB signaling pathway
- Focal adhesion
- Glioma
- Insulin signaling pathway
- Long-term depression
- Long-term potentiation
- MAPK signaling pathway
- Melanoma
- mTOR signaling pathway
- Natural killer cell mediated cytotoxicity
- Neurotrophin signaling pathway
- Non-small cell lung cancer
- Pancreatic cancer
- Pathways in cancer
- Prostate cancer
- Regulation of actin cytoskeleton
- Renal cell carcinoma
- Thyroid cancer
- Vascular smooth muscle contraction
- Related Disease
- Abnormalities, Multiple
- Adenocarcinoma
- Adenocarcinoma, Follicular
- Adenocarcinoma, Mucinous
- Adenocarcinoma, Papillary
- Adenoma
- Adenoma, Oxyphilic
- Adrenal Cortex Neoplasms
- Alcoholism
- Articulation Disorders
- Astrocytoma
- Brain Neoplasms
- Breast cancer
- Breast Neoplasms
- Carcinoma
- Carcinoma, Basal Cell
- Carcinoma, Medullary
- Carcinoma, Non-Small-Cell Lung
- Carcinoma, Papillary