PeproTech重組人IL-21 1000ug-細(xì)胞/細(xì)菌培養(yǎng)-試劑-生物在線

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美國PeproTech(派普泰克)公司中國代表處
PeproTech重組人IL-21 1000ug

PeproTech重組人IL-21 1000ug

商家詢價(jià)

產(chǎn)品名稱： PeproTech重組人IL-21 1000ug

英文名稱： Recombinant Human IL-21

產(chǎn)品編號： 200-21

產(chǎn)品價(jià)格： 0

產(chǎn)品產(chǎn)地： 美國

品牌商標(biāo)： PeproTech

更新時(shí)間： null

使用范圍： null

美國PeproTech(派普泰克)公司中國代表處
  • 聯(lián)系人 :
  • 地址 :  江蘇省蘇州市工業(yè)園區(qū)星湖街218號A1北座4樓L03
  • 郵編 : 215123
  • 所在區(qū)域 : 江蘇
  • 電話 : 點(diǎn)擊查看
  • 傳真 : 點(diǎn)擊查看
  • 郵箱 : peprotech.infochina@thermofisher.com






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Human Growth Factors & Cytokines


Recombinant Human IL-21







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		Synonyms :


none.







		Description :


IL-21 is a pleiotropic cytokine produced by CD4+ T cells in response to antigenic stimulation.  Its action generally enhances antigen-specific responses of immune cells.  The biological effects of IL-21 include induction of differentiation of T-cells-stimulated B-cells into plasma cells and memory B-cells, stimulation (in conjuction) with IL-4 of IgG production, and induction of apoptotic effects in na?ve B-cells and stimulated B-cells in the absence of T-cell signaling.  Additionally, IL-21 promotes the anti-tumor activity of CD8+ T-cells and NK cells.  IL-21 exerts its effect through binding to a specific type I cytokine receptor, IL-21R, which also contains the gamma chain (γc) found in other cytokine receptors including IL-2, IL-4, IL-7, IL-9 and IL-15.  The IL-21/IL-21R interaction triggers a cascade of events which includes activation of the tyrosine kinases JAK1 and JAK3, followed by activation of the transcription factors STAT1 and STAT3.  Recombinant human IL-21 is a 15.4 kDa protein consisting of 132 amino acid residues.







		Catalog #:


200-21







		Source :


E.coli







		Purity :


Greater than 98% by SDS-PAGE gel and HPLC analyses.







		Endotoxin Level :


Endotoxin level is less than 0.1 ng per μg (1EU/μg).







		Biological Activity :


Assay #1:Determined by its ability to proliferate activated B cells. 

 

Assay #2:Determined by its ability to induce human CD40L-activated na?ve B cells to undergo Ig isotype switching to IgG, using an IL-21 concentration of 50 ng/ml. Maximal activity was achieved after approximately five cell divisions.

Avery, D.T. et. al. (2008) J. Immunol. 181, 1767-1779.






Selected References :


Selected List of References Citing This PeproTech Product







                AA Sequence :


MQDRHMIRMR QLIDIVDQLK NYVNDLVPEF LPAPEDVETN CEWSAFSCFQ KAQLKSANTG NNERIINVSI KKLKRKPPST NAGRRQKHRL TCPSCDSYEK KPPKEFLERF KSLLQKMIHQ HLSSRTHGSE DS 







		PubMed Link :


IL-21






Country of Origin :


USA


























        Size A
2μg
$80?
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        Size B
10μg
$195?
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        Size C
1mg
$5200?
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Special 
                    Sizes: 
 Many products can be ordered in custom sizes. Please click here to contact Peprotech with your request.










Usage:
For Research Use Only.  Not for use in diagnostic or therapeutic procedures.