Recombinant Human IL-15
 
Catalog Number:
AF-200-15
Synonyms:
IL-T
Description:
IL-15 is an immunomodulating cytokine that stimulates the proliferation of T lymphocytes and shares many biological properties with IL-2. IL-15 exerts its biological activities primarily on T cells. It is also essential in the development, survival and activation of NK cells. Increased expression of IL-15 has been implicated with rheumatoid arthritis, inflammatory bowl disease and diseases affiliated with retroviruses HIV and HTLV-I. Human IL-15 is biologically active on mouse cells as measured by the dose-dependent stimulation of the proliferation of mouse CTLL cells. Recombinant human IL-15 is a 12.9 kDa protein consisting of 115 amino acid residues. Manufactured using all non-animal reagents.
AA Sequence:
MNWVNVISDL KKIEDLIQSM HIDATLYTES DVHPSCKVTA MKCFLLELQV ISLESGDASI HDTVENLIIL ANNSLSSNGN VTESGCKECE ELEEKNIKEF LQSFVHIVQM FINTS
Source:
E.coli
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
Determined by its ability to stimulate the proliferation of mouse CTLL-2 cells. The expected ED50 is ≤ 0.5 ng/ml, corresponding to a specific activity of ≥2 x 106 units/mg.
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Cross Reactivity:
Monkey, Mouse
Research Interests:
AIDS / HIV
Apoptosis
Cancer
Cell Culture
Immune System
Inflammation
Stem Cells & Differentiation
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Country of Origin:
USA
Research Use Only. Not for use in diagnostic or therapeutic procedures.