Depolarization-activated potassium channels (Kv) play a major role in shaping the electrical signals in the nervous
system (3). KvBeta2, otherwise known as potassium voltage gated
channel, shaker-related subfamily beta member 2, is
encoded by the KCNAB2 gene in humans. The KvBeta
channels are also members of the aldo-keto reductase (AKR)
subfamily. These proteins regulated inactivation and
membrane localization of Kv1 and Kv4 channels (4, 5).
Specifically Kv2beta2 contributes to regulation of excitability
in vivo, although not directly through either chaperone-like
or typical AKR catalytic activity (5).