Anti-14-3-3 sigma抗體[EPR5873(2)]-抗體-抗體-生物在線

產(chǎn)品名稱： Anti-14-3-3 sigma抗體[EPR5873(2)]

英文名稱： Anti-14-3-3 sigma抗體[EPR5873(2)]

產(chǎn)品編號： ab193667

產(chǎn)品價格： null

產(chǎn)品產(chǎn)地：英國

品牌商標： abcam

更新時間： null

使用范圍：

深圳市宇德立生物科技有限公司

進入展臺

描述
兔單克隆抗體[EPR5873(2)] to 14-3-3 sigma
經(jīng)測試應(yīng)用WB,?IHC-Pmore details
種屬反應(yīng)性
與反應(yīng):?Rat, Human
免疫原
Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human 14-3-3 sigma aa 50-150. The exact sequence is proprietary.
Database link:?P31947
陽性對照
- Human skin, A431 and HACAT lysates; Human 14-3-3 Sigma recombinant protein; Human tonsil tissue.
常規(guī)說明
This product is a recombinant rabbit monoclonal antibody.

Produced using Abcam’s RabMAb^??technology. RabMAb^??technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

形式Liquid
存放說明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
存儲溶液Preservative: 0.01% Sodium azide
Constituents: 59% PBS, 40% Glycerol, 0.05% BSA
濃度100 μl 濃度為 1.258 mg/ml?40 μl 濃度為 1.258 mg/ml?10 μl 濃度為 1.258 mg/ml?
純度Protein A purified
克隆單克隆
克隆編號EPR5873(2)
同種型IgG
研究領(lǐng)域
- Stem Cells
- Signaling Pathways
- Wnt
- 14-3-3

Our?Abpromise guarantee?covers the use of?ab193667?in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

應(yīng)用	Abreviews	說明
WB	?	1/1000 - 1/2000. Detects a band of approximately 28 kDa (predicted molecular weight: 27 kDa).
IHC-P	?	1/600. Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.

功能Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53.
p53-regulated inhibitor of G2/M progression.
組織特異性Present mainly in tissues enriched in stratified squamous keratinizing epithelium.
序列相似性Belongs to the 14-3-3 family.
翻譯后修飾Ubiquitinated. Ubiquitination by RFFL induces proteasomal degradation and indirectly regulates p53/TP53 activation.
細胞定位Cytoplasm. Nucleus. Secreted. May be secreted by a non-classical secretory pathway.
Information by UniProt
數(shù)據(jù)庫鏈接
- Entrez Gene: 2810?Human
- Entrez Gene: 313017?Rat
- Omim: 601290?Human
- SwissProt: P31947?Human
- Unigene: 523718?Human
別名
- 14 3 3 protein sigma antibody
- 14-3-3 protein sigma antibody
- 1433S_HUMAN antibody
see all

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