Anti- Inosine triphosphate pyrophosphatase抗體
產(chǎn)品名稱： Anti- Inosine triphosphate pyrophosphatase抗體
英文名稱： C20orf37 antibody dJ794I6.3 antibody HLC14-06-P antibody Inosine triphosphatase (nucleoside triphosphate pyrophosphatase) antibody Inosine triphospha
產(chǎn)品編號： ab118236
產(chǎn)品價格： null
產(chǎn)品產(chǎn)地： 英國
品牌商標： abcam
更新時間： null
使用范圍：
深圳市宇德立生物科技有限公司
- 聯(lián)系人 :
- 地址 : 深圳市寶安區(qū)西鄉(xiāng)寶民二路賢基大廈4E
- 郵編 :
- 所在區(qū)域 : 廣東
- 電話 : 133****4454 點擊查看
- 傳真 : 點擊查看
- 郵箱 : 1484332550@qq.com
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- 經(jīng)測試應(yīng)用WB,?IHC-Pmore details
- 種屬反應(yīng)性
與反應(yīng):?Human
預(yù)測可用于:?Mouse, Rat
- 免疫原
Recombinant fragment, corresponding to amino acids 21-177 of Human Inosine triphosphate pyrophosphatase (BC010138).
- 陽性對照
- Human fetal liver and heart lysate.
性能
- 形式Lyophilised:Reconstitute in 200ul sterile H2O. Human fetal heart tissue.
- 存放說明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
- 存儲溶液pH: 7.20
Preservative: 0.02% Sodium azide
Constituents: 1% BSA, 98% PBS -
濃度由溶解方法決定?
- 純度Immunogen affinity purified
- 克隆多克隆
- 同種型IgG
- 研究領(lǐng)域
應(yīng)用
Our?Abpromise guarantee?covers the use of?ab118236?in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
靶標
- 功能Hydrolyzes ITP and dITP to their respective monophosphate derivatives. Xanthosine 5'-triphosphate (XTP) is also a potential substrate. May be the major enzyme responsible for regulating ITP concentration in cells.
- 組織特異性Ubiquitous. Highly expressed in heart, liver, sex glands, thyroid and adrenal gland.
- 疾病相關(guān)Defects in ITPA are the cause of inosine triphosphate pyrophosphohydrolase deficiency (ITPA deficiency) [MIM:147520]. It is a common inherited trait characterized by the abnormal accumulation of inosine triphosphate (ITP) in erythrocytes and also leukocytes and fibroblasts. The pathological consequences of ITPA deficiency, if any, are unknown. However, it might have pharmacogenomic implications and be related to increased drug toxicity of purine analog drugs. Three different human populations have been reported with respect to their ITPase activity: high, mean (25% of high) and low activity. The variant Thr-32 is associated with complete loss of enzyme activity, may be by altering the local secondary structure of the protein. Heterozygotes for this polymorphism have 22.5% of the control activity: this is consistent with a dimeric structure of the enzyme.
- 序列相似性Belongs to the HAM1 NTPase family.
- 細胞定位Cytoplasm.
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Anti- Inosine triphosphate pyrophosphatase antibody 圖像
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Western blot - Anti- Inosine triphosphate pyrophosphatase antibody (ab118236)All lanes :?Anti- Inosine triphosphate pyrophosphatase antibody (ab118236) at 1/1000 dilution
Lane 1 :?Human fetal liver lysate
Lane 2 :?Human fetal heart lysate
Predicted band size :?21 kDa
Observed band size :?21 kDa
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti- Inosine triphosphate pyrophosphatase antibody (ab118236)ab118236 at 1/100 staining Inosine triphosphate pyrophosphatase in paraffin-embedded Human fetal heart lysate tissue by Immunohistochemistry.
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