WT1 Rabbit pAb (APR22903N)
產(chǎn)品名稱： WT1 Rabbit pAb (APR22903N)
英文名稱： WT1 Rabbit pAb (APR22903N)
產(chǎn)品編號(hào)： APR22903N
產(chǎn)品價(jià)格： null
產(chǎn)品產(chǎn)地： 美國
品牌商標(biāo)： Leading Biology
更新時(shí)間： null
使用范圍：
生物谷
- 聯(lián)系人 : 請(qǐng)聯(lián)系郵箱
- 地址 : 上海市徐匯區(qū)光啟城辦公樓3樓
- 郵編 : 100176
- 所在區(qū)域 : 上海
- 電話 : business@bioon.com 點(diǎn)擊查看
- 傳真 : 點(diǎn)擊查看
- 郵箱 : business@bioon.com
分子量：Calculated MW: 33kDa/34kDa/47kDa/48kDa/49kDa/55kDa/56kDa Observed MW: 49kDa 細(xì)胞定位：Cytoplasm, Nucleus, Nucleus speckle, nucleolus, nucleoplasm 稀釋方法：WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 總結(jié)：This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumor. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation codon upstream of, and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated.