PD-L1/CD274/B7-H1
產(chǎn)品名稱： PD-L1/CD274/B7-H1
英文名稱： PD-L1/CD274/B7-H1
產(chǎn)品編號(hào)： GMP-TL727
產(chǎn)品價(jià)格：
產(chǎn)品產(chǎn)地： China
品牌商標(biāo)： 同立海源生物
更新時(shí)間： 2023-08-24T13:10:36
使用范圍： null
| 規(guī)格 | 價(jià)格 |
| 100μg | 3000.0 |
- 聯(lián)系人 : 崔女士
- 地址 : 北京市大興區(qū)中關(guān)村科技園區(qū)大興生物醫(yī)藥產(chǎn)業(yè)基地華佗路50號(hào)院13號(hào)樓
- 郵編 : 100085
- 所在區(qū)域 : 北京
- 電話 : 186****3653 點(diǎn)擊查看
- 傳真 : 點(diǎn)擊查看
- 郵箱 : cuilimei@seafrom.cn
重組人PD-L1蛋白（Recombinant Human PD-L1 Protein），GMP級(jí)
產(chǎn)品貨號(hào)：GMP-TL727
產(chǎn)品描述（Description）
Programmed cell death 1 ligand 1 (PD-L1) is also known as cluster of differentiation (CD274) or B7 homolog 1 (B7-H1), is a member of the growing B7 family of immune molecules and is involved in the regulation of cellular and humoral immune responses. B7-H1 is a cell surface immunoglobulin superfamily with two Ig-like domains within the extracellular region and a short cytoplasmic domain. PD-L1 is highly expressed in the heart, skeletal muscle, placenta and lung and weakly expressed in the thymus, spleen, kidney and liver. PD-L1 is expressed on activated T-cells, B-cells, dendritic cells, keratinocytes and monocytes. PD-L1 is up-regulated on T- and B-cells, dendritic cells, keratinocytes and monocytes after LPS and IFNG activation and up-regulated in B-cells activated by surface Ig cross-linking. PD-L1 involve in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner.
分子別名（Synonym）
CD274、B7-H1、PDCD1L1、PDCD1LG1
表達(dá)宿主（Expression host）
HEK293細(xì)胞
來源（Source）
Human
蛋白序列（Protein Sequence）
DNA序列編碼人PD-L1（NCBI Reference Sequence:NP_054862.1）表達(dá)帶有His標(biāo)簽在C末端
分子量（Molecular Weight）
重組人PD-L1蛋白 包含222個(gè)氨基酸，預(yù)測(cè)理論分子量為26.9 kD
純度（Purity）
≥95%采用SDS-PAGE凝膠和高效液相色譜分析
內(nèi)毒素（Endotoxin）
＜0.1EU/ug
生物活性（Biological Activity）
固定 PD-L1(His 標(biāo)簽)1ug/mL(100 uL/孔)能夠結(jié)合抗人PD-L1抗體的線性范圍是0.5-5 ng/mL
穩(wěn)定性（Stability）
凍干制劑可在 4℃保存 24 個(gè)月， 溶解后的液體可置于-20℃保存 6-12 個(gè)月， 避免反復(fù)凍融
組成（Component）
含有6%甘露醇的無菌PBS（PH 7.4）的凍干粉
參考文獻(xiàn)
1. DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells Hiro Sato, Atsuko Niimi, Takaaki Yasuhara, Tiara Bunga Mayang Permata, Yoshihiko Hagiwara, Mayu Isono, Endang Nuryadi, Ryota Sekine, Takahiro Oike, Sangeeta Kakoti, Yuya Yoshimoto, Kathryn D. Held, Yoshiyuki Suzuki, Koji Kono, Kiyoshi Miyagawa, Takashi Nakano, Atsushi Shibata Nat Commun. 2017; 8: 1751. Published online 2017 Nov 24. doi: 10.1038/s41467-017-01883-9
注意：For research and manufacturing use.