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Human Growth Factors & Cytokines
            
Recombinant Human TNF-alpha
            

            

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Synonyms :
                        
                        

                        
Tumor Necrosis Factor, TNFSF2, Cachectin, Differentiation-inducing factor (DIF), Necrosin, Cytotoxin
                        
                    
                    

                        

                        
Description :
                        
                        

                        
TNF-α is a pleiotropic pro-inflammatory cytokine secreted by various cells including adipocytes, activated monocytes, macrophages, B cells, T cells and fibroblasts. It belongs to the TNF family of ligands and signals through two receptors, TNFR1 and TNFR2. TNF-α is cytotoxic to a wide variety of tumor cells and is an essential factor in mediating the immune response against bacterial infections. TNF-α also plays a role in the induction of septic shock, auto immune diseases, rheumatoid arthritis, inflammation, and diabetes. Recombinant human TNF-α is a soluble 157 amino acid protein (17.4 kDa) which corresponds to C-terminal extracellular domain of the full length transmembrane protein.
                        
                    
                    

                        

                        
Catalog #:
                        
                        

                        
300-01A
                        
                    
                    

                        

                        
Source :
                        
                        

                        
E.coli
                        
                    
                    

                        

                        
Purity :
                        
                        

                        
Greater than 98% by SDS-PAGE gel and HPLC analyses.
                        
                    
                    

                        

                        
Endotoxin Level :
                        
                        

                        
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
                        
                    
                    

                        

                        
Biological Activity :
                        
                        

                        
The ED50 as determined by the cytolysis of murine L929 cells in the presence of Actinomycin D is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 107 units/mg.
                        
                    
                    

                        

                        
Selected References :
                        
                        

                        
Selected List of References Citing This PeproTech Product
                        
                    
                    

                        

                        
AA Sequence :
                        
                        

                        
VRSSSRTPSD KPVAHVVANP QAEGQLQWLN RRANALLANG VELRDNQLVV PSEGLYLIYS QVLFKGQGCP STHVLLTHTI SRIAVSYQTK VNLLSAIKSP CQRETPEGAE AKPWYEPIYL GGVFQLEKGD RLSAEINRPD YLDFAESGQV YFGIIAL 
                        
                    
                    

                        

                        
PubMed Link :
                        
                        

                        
TNFalpha+AND+human
                        
                    
                    

                        

                        
Country of Origin :
                        
                        

                        
USA
                        
                    
                    

                        
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Size A
                                    
10μg
                                    
$80?
                                    
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Size B
                                    
50μg
                                    
$195?
                                    
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Size C
                                    
1mg
                                    
$1500?
                                    
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Special Sizes: 

                        Many products can be ordered in custom sizes. Please click here to contact Peprotech with your request.
                        
                    
                    

                        

                        
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Usage:

                        For Research Use Only. Not for use in diagnostic or therapeutic procedures. 
                        
                    
                
            
            

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