BRSK1 Rabbit pAb (APR23577N)
產(chǎn)品名稱： BRSK1 Rabbit pAb (APR23577N)
英文名稱： BRSK1 Rabbit pAb (APR23577N)
產(chǎn)品編號： APR23577N
產(chǎn)品價格： null
產(chǎn)品產(chǎn)地： 美國
品牌商標： Leading Biology
更新時間： null
使用范圍：
分子量：Calculated MW: 38kDa/85kDa/86kDa Observed MW: 90KDa 細胞定位：Cell junction, Cytoplasm, Nucleus, centrosome, cytoskeleton, microtubule organizing center, synapse 稀釋方法：WB 1:500 - 1:2000 IHC 1:50 - 1:200 總結：Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2 at 'Ser-131', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C.