Anti-Orai1 Rabbit Polyclonal Antibody (Orai1-L2)-抗體-抗體-生物在線
武漢紐斯特生物技術有限公司
Anti-Orai1 Rabbit Polyclonal Antibody (Orai1-L2)

Anti-Orai1 Rabbit Polyclonal Antibody (Orai1-L2)

商家詢價

產品名稱： Anti-Orai1 Rabbit Polyclonal Antibody (Orai1-L2)

英文名稱： Anti-Orai1 Rabbit Polyclonal Antibody (Orai1-L2)

產品編號： 21002

產品價格： null

產品產地： 美國

品牌商標： NewEastbio

更新時間： null

使用范圍： ELISA, WB

武漢紐斯特生物技術有限公司
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Orai1-L2 [21002]
[100 μL]		 ?

Catalog Number:??21002
Gene Symbol:??Orai1
Description: ??Anti-Orai1 Rabbit Polyclonal Antibody (Orai1-L2)
Background: ??Store-operated calcium channels (SOCs) play essential functions in various physiological processes. Orai1 (also named CRACM1) is a critical molecular component of SOCs. Orai1 protein is a ~35 kDa plasma membrane protein with 4 transmembrane domains. Human patients with a severe combinaed immunodeficiency (SCID) syndrome possess point mutations in Orai1 gene.
Immunogen: ??A peptide from the extracellular loop 2 region of human Orai1
Applications: ??ELISA, WB
Recommended Dilutions: ??
ELISA:??????1:1000-1:5000,
WB:??????????1:1000-1:2000,
IHC:??????????1:100-1:200
Concentration: ??
Host: ??Rabbit
Format: ??Liquid
Clonality: ??Polyclonal
Isotype: ??IgG
Purity: ??Immunogen affinity purified
Storage buffer:
Preservative:??0.01% sodium azide
Constituents:?? 50mM NaHCO3-Glycine, 0.15M NaCl,, pH7.4
Species Reactivity:??Orai1-L2 antibody recognizes Orai1 from human.
Storage Conditions:??Store at -20°C. Avoid freeze / thaw cycles
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Western blot:??
Western blot analysis of Orai1 protein. Human Orai1 plasmid DNA was transiently transfected into HEK-293 cells. Whole-cell lysate was used for western blot in the absence (A) or presence (B) of antigen peptide.

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Publications:
1.??Generation and Characterization of Fully Human Monoclonal Antibodies Against Human Orai1 for Autoimmune Disease
????J Pharmacol Exp Ther. 2013 May;345(2):225-38
2.??Influence of Orai1 intervention on mouse airway epithelium reactions in vivo and in vitro
????Ann Allergy Asthma Immunol. 2012 Feb;108(2):103-12
3.??2-Aminoethoxydiphenyl borate administration into the nostril alleviates murine allergic rhinitis
????Am J Otolaryngol. 2011 Jul-Aug;32(4):318-28
4.??Up-regulation of Orai1 in murine allergic rhinitis
????Histochem Cell Biol. 2010 Jul;134(1):93-102
5.??Orai1 and STIM1 are critical for breast tumor cell migration and metastasis
????Cancer Cell. 2009 Feb 3;15(2):124-34
6.??Amelioration of Muc5b mucin hypersecretion is enhanced by IL-33 after 2-APB administration in a murine model of allergic rhinitis
????Biotech Histochem. 2014 May;89(4):273-86