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Size??100ug
Cat code??310008
Species Cross-reactivity??H,M
Key Application??WB
Host??Rabbit
Antibody type??Polyclonal antibody
Purified method??Affinity purified
Isotype??
Molecular Weight??43kDa
Sensitivity??The antibody detects endogenous level of total P38MAPK protein.
Immunogen??Peptide sequence around aa. 180~184 (T-G-Y-V-A) derived from Human P38 MAPK.
UniProt Number??O15264
GeneBank ID??NM_001315.2
Subcellular location??Nucleus, Nucleoli, Cytoplasm
Formulation??Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Altername??CSAID Binding Protein 1 ;CSAID binding protein ;CSAID-binding protein ; Csaids binding protein ;CSBP 1 ;CSBP 2 ;CSBP ;CSBP1 ;CSBP2 ;CSPB 1 ;CSPB1 ;Cytokine suppressive anti inflammatory drug binding protein ;Cytokine suppressive anti-inflammatory drug-binding protein ;EXIP ;MAP kinase 14 ;MAP kinase MXI2 ;MAP kinase p38 alpha ;MAPK 14 ;MAPK14 ;MAX interacting protein 2 ;MAX-interacting protein 2 ;Mitogen Activated Protein Kinase 14 ;Mitogen activated protein kinase p38 alpha ;Mitogen-activated protein kinase 14 ;Mitogen-activated protein kinase p38 alpha ;MK14_HUMAN ;Mxi 2 ;Mxi2 ;p38 ALPHA ;p38 ;p38 MAP kinase ;p38 MAPK ;p38 mitogen activated protein kinase ;p38ALPHA ;p38alpha Exip ;PRKM14 ;PRKM15 ;RK ;SAPK 2A ;SAPK2A ;Stress Activated Protein Kinase 2A.
Gene_symbol??SAPK4; PRKM13; MAPK 13; MAPK-13; p38delta
Summary??This gene encodes a member of the mitogen-activated protein (MAP) kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The encoded protein is a p38 MAP kinase and is activated by proinflammatory cytokines and cellular stress. Substrates of the encoded protein include the transcription factor ATF2 and the microtubule dynamics regulator stathmin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]
UniPort summary  Function??Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studied p38 MAPK isoforms. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K. Involved in cytoskeletal remodeling through phosphorylation of MAPT and STMN1. Mediates UV irradiation induced up-regulation of the gene expression of CXCL14. Plays an important role in the regulation of epidermal keratinocyte differentiation, apoptosis and skin tumor development. Phosphorylates the transcriptional activator MYB in response to stress which leads to rapid MYB degradation via a proteasome-dependent pathway. MAPK13 also phosphorylates and down-regulates PRKD1 during regulation of insulin secretion in pancreatic beta cells.
Application Images :??
Western blot detection of p38 MAPK antibody in 3T3 and Hela cell lysates using p38 MAPK antibody(dilution 1:300). Predicted band size:43KDa. Observed band size:43KDa.