MAP2K1/MAP2K2 (phospho S217/221) polyclonal antibody
產品名稱： MAP2K1/MAP2K2 (phospho S217/221) polyclonal antibody
英文名稱： MAP2K1/MAP2K2 (phospho S217/221) polyclonal antibody
產品編號： PAB17923
產品價格： null
產品產地： 臺灣
品牌商標： Abnova
更新時間： null
使用范圍：
亞諾法生技股份有限公司（Abnova)
- 聯系人 :
- 地址 : 臺灣臺北市內湖區洲子街 108 號 9 樓
- 郵編 : 11493
- 所在區域 : 臺灣
- 電話 : +886-920**1152 點擊查看
- 傳真 : 點擊查看
- 郵箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic phosphopeptide of MAP2K1/MAP2K2.
- Immunogen:
- Synthetic phosphopeptide corresponding to residues surrounding S217/221 of human MAP2K1/MAP2K2.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse, Rat
- Specificity:
- This antibody recognizes 45 KDa phospho-Mek1/2 (Ser217/221). It does not detect the unphosphorylated protein.
- Form:
- Liquid
- Purification:
- Affinity purification
- Storage Buffer:
- In PBS (50% glycerol, 1% BSA, 0.02% sodium azide)
- Storage Instruction:
- Store at -20°C. For long term storage store at -80°.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (1:200-1:1000)
Immunocytochemistry (1:100-1:200)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Application Image
- Western Blot
- Immunofluorescence
- Entrez GeneID:
- 5604
- Protein Accession#:
- Q02750
- Gene Name:
- MAP2K1
- Gene Alias:
- MAPKK1,MEK1,MKK1,PRKMK1
- Gene Description:
- mitogen-activated protein kinase kinase 1
- Omim ID:
- 176872
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development. [provided by RefSeq
- Other Designations:
- protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1)
- Entrez GeneID:
- 5605
- Protein Accession#:
- Q02750
- Gene Name:
- MAP2K2
- Gene Alias:
- FLJ26075,MAPKK2,MEK2,MKK2,PRKMK2
- Gene Description:
- mitogen-activated protein kinase kinase 2
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. [provided by RefSeq
- Other Designations:
- ERK activator kinase 2,MAP kinase kinase 2,MAPK/ERK kinase 2,dual specificity mitogen-activated protein kinase kinase 2,mitogen-activated protein kinase kinase 2, p45