重組人OX40 Ligand蛋白
產品名稱: 重組人OX40 Ligand蛋白
英文名稱: Human OX40 Ligand Protein
產品編號: GMP-TL726
產品價格:
產品產地: 中國
品牌商標: 同立海源生物
更新時間: 2023-08-25T16:14:15
使用范圍: null
| 規格 | 價格 |
| 100μg | 3000.0 |
- 聯系人 : 崔女士
- 地址 : 北京市大興區中關村科技園區大興生物醫藥產業基地華佗路50號院13號樓
- 郵編 : 100085
- 所在區域 : 北京
- 電話 : 186****3653 點擊查看
- 傳真 : 點擊查看
- 郵箱 : cuilimei@seafrom.cn
重組人OX40蛋白(Recombinant Human OX40 Protein),GMP級
產品貨號:GMP-TL725
產品描述(Description)
Tumor necrosis factor receptor superfamily member 4 (TNFRSF4) is also known as ACT35 antigen, OX40L receptor, TAX transcriptionally-activated glycoprotein 1 receptor, CD antigen CD134, OX40. OX40 / TNFRSF4 contains four TNFR-Cys repeats. TNFRSF4 is receptor for TNFSF4 / OX40L / GP34 and can interacts with TRAF2, TRAF3 and TRAF5.
分子別名(Synonym)
TNFRSF4、CD134、OX40L receptor、ACT35、TXGP1L
表達宿主(Expression host)
HEK293細胞
來源(Source)
Human
蛋白序列(Protein Sequence)
DNA序列編碼人OX40(NCBI Reference Sequence:NP_003318.1)表達帶有His標簽在C末端
分子量(Molecular Weight)
重組人OX40蛋白包含189個氨基酸,預測理論分子量為21.8 kD
純度(Purity)
≥95%采用SDS-PAGE凝膠和高效液相色譜分析
內毒素(Endotoxin)
<0.1EU/ug
生物活性(Biological Activity)
固定人OX40(His 標簽)1ug/mL (100uL/孔)能結合人OX40 Ligand(Fc 標簽)的線性范圍是1-10ng/mL
穩定性(Stability)
凍干的樣本的可以在4℃保存24個月,溶解后的液體可以于-20℃保存6~12個月,并且避免反復凍融
組成(Component)
含有6%甘露醇的無菌PBS(PH 7.4)的凍干粉
參考文獻
1、1. Fc Engineering Approaches to Enhance the Agonism and Effector Functions of an Anti-OX40 AntibodyDi Zhang, Monica V. Goldberg, Mark L. ChiuJ Biol Chem. 2016 Dec 30; 291(53): 27134–27146. Published online 2016 Nov 17. doi: 10.1074/jbc.M116.757773
2、Small-molecule modulators of the OX40–OX40 ligand co-stimulatory protein–protein interaction Yun Song, Emilio Margolles-Clark, Allison Bayer, Peter Buchwald Br J Pharmacol. 2014 Nov; 171(21): 4955–4969. Published online 2014 Oct 24. doi: 10.1111/bph.12819
3、PD-1 co-inhibitory and OX40 co-stimulatory crosstalk regulates helper T cell differentiation and anti-Plasmodium humoral immunity Ryan A. Zander, Nyamekye Obeng-Adjei, Jenna J. Guthmiller, Divine I. Kulu, Jun Li, Aissata Ongoiba, Boubacar Traore, Peter D. Crompton, Noah S. Butler Cell Host Microbe. Author manuscript; available in PMC 2016 May 13.Published in final edited form as: Cell Host Microbe. 2015 May 13; 17(5): 628–641. Published online 2015 Apr 16. doi: 10.1016/j.chom.2015.03.007
注意:For research and manufacturing use.
