Product Highlight

• Configuration-specific monoclonal antibody that recognizes RheB-GTP, but not RheB-GDP
• The only available RheB activation assay kit directly measures the level of RheB-GTP
• Providing shorter experimental time
• Could be used to monitor the activation of RheB in cells and in tissues by immunohistochemistry

Product Description

Small GTPases are a super-family of cellular signaling regulators. RheB is a member of the Ras-superfamily GTPases. RheB has been shown to interact with C-Raf, Mammalian target of rapamycin (mTOR), TSC2, Ataxia telangiectasia mutated (ATM), KIAA1303 and Ataxia telangiectasia and Rad3 related.

Currently there is no direct assay to measure the activation of RheB GTPases.

NewEast Biosciences RheB Activation Assay Kit is based on the configuration-specific monoclonal antibody that specifically recognizes RheB-GTP, but not RheB-GDP. Given the high affinity of monoclonal antibodies to their antigens, the activation assay could be performed in a short time. This assay provides the reliable results with consistent reproducibility.

These anti-RheB-GTP monoclonal antibody can also be used to monitor the activation of RheB in cells and in tissues by immunohistochemistry.

NewEast Biosciences RheB Activation Assay Kit provides a simple and fast method to monitor the activation of RheB. Each kit provides sufficient quantities to perform 20 assays.