Size??100ug
Cat code??200758
Species Cross-reactivity??H
Key Application??WB
Host??Mouse
Antibody type??Monoclonal antibody
Purified method??null
Isotype??IgG2b
Molecular Weight??60kDa
Sensitivity??This antibody detects endogenous levels of CYP17A1 and does not cross-react with related proteins.
Immunogen??Purified recombinant human CYP17A1 protein fragments expressed in E.coli.
UniProt Number??P05093
GeneBank ID??NM_000102
Subcellular location??Membrane.
Formulation??Ascites
Altername??20 lyase;CP17A_HUMAN;CPT7;CYP17;CYP17A1;CYPXVII;Cytochrome P450 17A1;Cytochrome P450 family 17;Cytochrome P450 family 17 subfamily A polypeptide 1;Cytochrome p450 subfamily XVII (steroid 17 alpha hydroxylase) adrenal hyperplasia;Cytochrome p450 XVIIA1;Cytochrome P450-C17;Cytochrome P450c17;OTTHUMP00000020382;P450 C17;P450c17;S17AH;Steroid 17 alpha hydroxylase/17,20 lyase;Steroid 17 alpha monooxygenase;Steroid 17-alpha-hydroxylase/17;Steroid 17-alpha-monooxygenase.
Gene_symbol??CPT7;CYP17;S17AH;P450C17
Summary??This gene encodes a member of the cytochrome P450 superfamily of enzymes.The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol,steroids and other lipids.This protein localizes to the endoplasmic reticulum.It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins,mineralocorticoids,glucocorticoids,androgens,and estrogens.Mutations in this gene are associated with isolated steroid-17 alpha-hydroxylase deficiency,17-alpha-hydroxylase/17,20-lyase deficiency,pseudohermaphroditism,and adrenal hyperplasia.[provided by RefSeq,Jul 2008]
UniPort summary  Function??Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione.Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction.Involved in sexual development during fetal life and at puberty.
Application Images :??
Western blot detection of CYP17A1 antibody in Hela，HepG2 and A549 cell lysates using CYP17A1 antibody (1:1000 diluted).Predicted band size:60KDa.Observed band size:60KDa.