ACAN polyclonal antibody
產品名稱： ACAN polyclonal antibody
英文名稱： ACAN polyclonal antibody
產品編號： PAB18067
產品價格： null
產品產地： 臺灣
品牌商標： Abnova
更新時間： null
使用范圍：
亞諾法生技股份有限公司（Abnova)
- 聯系人 :
- 地址 : 臺灣臺北市內湖區洲子街 108 號 9 樓
- 郵編 : 11493
- 所在區域 : 臺灣
- 電話 : +886-920**1152 點擊查看
- 傳真 : 點擊查看
- 郵箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of ACAN .
- Immunogen:
- A synthetic peptide corresponding to amino acids 336-369 of human ACAN.
- Sequence:
- FFGVGGEED
- Host:
- Rabbit
- Reactivity:
- Human, Rat
- Specificity:
- This antibody is specific to endogenous levels of fragment of activated ACAN resulting from cleavage adjacent to Asp369.
- Form:
- Liquid
- Storage Buffer:
- In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (1:500~1:1000)
Immunohistochemistry (1:50~1:100)
ELISA(1:20000)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Aggrecan glycoforms contribute to the molecular heterogeneity of perineuronal nets.
Matthews RT, Kelly GM, Zerillo CA, Gray G, Tiemeyer M, Hockfield S.J Neurosci. 2002 Sep 1;22(17):7536-47.
- 2.
- SOX9 enhances aggrecan gene promoter/enhancer activity and is up-regulated by retinoic acid in a cartilage-derived cell line, TC6.
Sekiya I, Tsuji K, Koopman P, Watanabe H, Yamada Y, Shinomiya K, Nifuji A, Noda M.J Biol Chem. 2000 Apr 14;275(15):10738-44.
- 3.
- Overexpression of a single helix-loop-helix-type transcription factor, scleraxis, enhances aggrecan gene expression in osteoblastic osteosarcoma ROS17/2.8 cells.
Liu Y, Watanabe H, Nifuji A, Yamada Y, Olson EN, Noda M.J Biol Chem. 1997 Nov 21;272(47):29880-5.
- Applications
- Western Blot (Cell lysate)
- Western blot analysis of extracts from Jurkat cells, treated with Etoposide (25 uM, 60 mins), using ACAN polyclonal antibody (Cat # PAB18067).
Peptide "+" means "with peptide blocking".
- Entrez GeneID:
- 176
- Protein Accession#:
- P16112
- Gene Name:
- ACAN
- Gene Alias:
- AGC1,AGCAN,CSPG1,CSPGCP,MSK16,SEDK
- Gene Description:
- aggrecan
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene is a member of the aggrecan/versican proteoglycan family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage. Mutations in this gene may be involved in skeletal dysplasia and spinal degeneration. Multiple alternatively spliced transcript variants that encode different protein isoforms have been observed in this gene. [provided by RefSeq
- Other Designations:
- aggrecan 1 (chondroitin sulfate proteoglycan 1, large aggregating proteoglycan, antigen identified by monoclonal antibody A0122),aggrecan proteoglycan,cartilage-specific proteoglycan core protein,chondroitin sulfate proteoglycan 1,large aggregating proteo
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