重組人Galectin-9蛋白（Recombinant Human Galectin-9 Protein），GMP級

產品貨號：GMP-TL719

產品描述（Description）

Galectin-9 (LGALS9) is also known as tumor antigen HOM-HD-21 and ecalectin. Galectins are a family of proteins defined by their binding specificity for β-galactoside sugars, such as N-acetyllactosamine (Galβ1-3GlcNAc or Galβ1-4GlcNAc), which can be bound to proteins by either N-linked or O-linked glycosylation. As for Galectin-9, it has high affinity for the Forssman pentasaccharide, and it is also the ligand for HAVCR2/TIM3. Forthermore, Galectin-9 stimulates bactericidal activity in infected macrophages by causing macrophage activation and IL1B secretion which restricts intracellular bacterial growth.

分子別名（Synonym）

LGALS9、Ecalectin

表達宿主（Expression host）

HEK293細胞

來源（Source）

Human

蛋白序列（Protein Sequence）

DNA序列編碼人Galectin-9（NCBI ReferenceSequence:NP_002299.2）表達帶有His標簽在C末端

分子量（Molecular Weight）

重組人Galectin-9蛋白 包含323個氨基酸，預測理論分子量為37.4 kD

純度（Purity）

≥95%采用 SDS-PAGE 凝膠和高效液相色譜分析

內毒素（Endotoxin）

＜0.1EU/ug

生物活性（Biological Activity）

固定蛋白檢測其對 Jurkat 細胞（人急性 T 淋巴白血病細胞）的黏附遷移性的作用，該作用的 ED??是 1.1-4.2ug/mL

穩定性（Stability）

凍干制劑可在 4℃保存 24 個月， 溶解后的液體可置于-20℃保存 6-12 個月， 避免反復凍融

組成（Component）

含有6%甘露醇的無菌PBS（PH 7.4）的凍干粉

參考文獻

1、Astrocyte galectin-9 potentiates microglial TNF secretionAndrew J Steelman, Jianrong Li J Neuroinflammation. 2014; 11: 144. Published online 2014 Aug 27. doi: 10.1186/s12974-014-0144-0 

2、Galectin-9 binds IgM-BCR to regulate B cell signaling Anh Cao, Nouf Alluqmani, Fatima Hifza Mohammed Buhari, Laabiah Wasim, Logan K. Smith, Andrew T. Quaile, Michael Shannon, Zaki Hakim, Hossai Furmli, Dylan M. Owen, Alexei Savchenko, Bebhinn Treanor Nat Commun. 2018; 9: 3288. Published online 2018 Aug 17. doi: 10.1038/s41467-018-05771-8 

3、Cancer Therapy Due to Apoptosis: Galectin-9 Koji Fujita, Hisakazu Iwama, Kyoko Oura, Tomoko Tadokoro, Eri Samukawa, Teppei Sakamoto, Takako Nomura, Joji Tani, Hirohito Yoneyama, Asahiro Morishita, Takashi Himoto, Mitsuomi Hirashima, Tsutomu Masaki Int J Mol Sci. 2017 Jan; 18(1): 74. Published online 2017 Jan 1. doi: 10.3390/ijms18010074

  注意：For research and manufacturing use.