?中文名稱?轉錄因子SOX10重組兔單克隆抗體?
別? ? 名 DOM; MGC15649; SOX 10; SOX10_HUMAN; SRY (sex determining region Y) box 10; SRY box containing gene 10; SRY related HMG box gene 10; Transcription factor SOX 10; Transcription factor SOX-10; WS4.? ?
研究領域 細胞生物? 免疫學? 神經生物學? 干細胞? 細胞凋亡? 表觀遺傳學? ?
抗體來源 Rabbit?
克隆類型 Monoclonal?
克 隆 號 26D7?
交叉反應 (predicted: Human, Mouse, Rat, )?
產品應用 WB=1:500-1000 IP=1:20-100 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 IF=1:50-200 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.?
分 子 量 50kDa?
細胞定位 細胞核 細胞漿??
性? ? 狀 Liquid?
濃? ? 度 1mg/ml?
免 疫 原 Recombinant human SOX10 protein (350-450aa):??
亞? ? 型 IgG?
純化方法 affinity purified by Protein A?
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.?
保存條件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.?
PubMed PubMed?
產品介紹 This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development. Mutations in this gene are associated with Waardenburg-Shah and Waardenburg-Hirschsprung disease. [provided by RefSeq, Jul 2008]
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Function:
Transcription factor that seems to function synergistically with the POU domain protein TST-1/OCT6/SCIP. Could confer cell specificity to the function of other transcription factors in developing and mature glia.
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Subcellular Location:
Cytoplasm. Nucleus
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Tissue Specificity:
Expressed in fetal brain and in adult brain, heart, small intestine and colon.
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DISEASE:
Defects in SOX10 are the cause of Waardenburg syndrome type 2E (WS2E) [MIM:611584]. WS2 is a genetically heterogeneous, autosomal dominant disorder characterized by sensorineural deafness, pigmentary disturbanc
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