玻瑪西尼 Abemaciclib 1231929-97-7
產品名稱： 玻瑪西尼 Abemaciclib 1231929-97-7
英文名稱： Abemaciclib
產品編號： 1231929-97-7
產品價格： 0
產品產地： 國外
品牌商標： MEDKOO
更新時間： null
使用范圍： null
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Description:?Abemaciclib, also known as LY2835219, is orally available cyclin-dependent kinase (CDK) inhibitor that targets the CDK4 (cyclin D1) and CDK6 (cyclin D3) cell cycle pathway, with potential antineoplastic activity. LY2835219 inhibits CDK4 and CDK6 with low nanomolar potency. LY2835219 specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation in early G1. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth.
CAS#: 1231929-97-7 (free base)
Chemical Formula: C27H32F2N8
Exact Mass: 506.2718
Molecular Weight: 506.59
Elemental Analysis: C, 64.01; H, 6.37; F, 7.50; N, 22.12
Synonym:?LY2835219; LY2835219; LY 2835219; Abemaciclib.
IUPAC/Chemical Name:?N-(5-((4-ethylpiperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine
InChi Key:?UZWDCWONPYILKI-UHFFFAOYSA-N
InChi Code:?InChI=1S/C27H32F2N8/c1-5-35-8-10-36(11-9-35)16-19-6-7-24(30-14-19)33-27-31-15-22(29)25(34-27)20-12-21(28)26-23(13-20)37(17(2)3)18(4)32-26/h6-7,12-15,17H,5,8-11,16H2,1-4H3,(H,30,31,33,34)
SMILES Code:?CC1=NC2=C(F)C=C(C3=NC(NC4=NC=C(CN5CCN(CC)CC5)C=C4)=NC=C3F)C=C2N1C(C)C
Appearance:?White to off-white solid powder
Purity:?>98% (or refer to the Certificate of Analysis)
Shipping Condition:?Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition:?Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility:?Soluble in DMSO, not in water
Shelf Life:?>2 years if stored properly
Drug Formulation:?This drug may be formulated in DMSO
Stock Solution Storage:?0-4 C for short term (weeks), and -20 C for long term (months)
HS Tariff Code:?2934.99.9001