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Human, Murine & Rat Neurotrophins
Recombinant Human beta-NGF





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		Synonyms :
NGF-beta



		Description :
Beta-NGF is a neurotrophic factor structurally related to BDNF, NT-3 and NT-4.  These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures.  Beta-NGF is a potent neurotrophic factor that signals through its receptor beta-NGFR, and plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems.  Beta-NGF also acts as a growth and differentiation factor for B lymphocytes and enhances B-cell survival.  The functional form of human beta-NGF is a noncovalently disulfide-linked homodimer, of two 13.5 kDa polypeptide monomers (240 total amino acid residues).  The three disulfide bonds are required for biological activity.



		Catalog #:
450-01



		Source :
E.coli



		Purity :
Greater than 98% by SDS-PAGE gel and HPLC analyses.



		Endotoxin Level :
Endotoxin level is less than 0.1 ng per μg (1EU/μg).



		Biological Activity :
determined by its ability to stimulate chick E9 DRG neurite outgrowth.  The ED50 is < 1.0 ng/ml, corresponding to a specific activity of > 1 x 106 units/mg.


Selected References :
Selected List of References Citing This PeproTech Product



                AA Sequence :
SSSHPIFHRG EFSVCDSVSV WVGDKTTATD IKGKEVMVLG EVNINNSVFK QYFFETKCRD PNPVDSGCRG IDSKHWNSYC TTTHTFVKAL TMDGKQAAWR FIRIDTACVC VLSRKAVRRA 



		PubMed Link :
NGF+AND+human


Country of Origin :
USA
















        Size A
5μg
$80?
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        Size B
20μg
$195?
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        Size C
1mg
$3000?
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Special 
                    Sizes: 
 Many products can be ordered in custom sizes. Please click here to contact Peprotech with your request.





Usage:
For Research Use Only.  Not for use in diagnostic or therapeutic procedures.