ITGAM monoclonal antibody, clone MEM-174 (PE)
產(chǎn)品名稱： ITGAM monoclonal antibody, clone MEM-174 (PE)
英文名稱： ITGAM monoclonal antibody, clone MEM-174 (PE)
產(chǎn)品編號： MAB4552
產(chǎn)品價格： null
產(chǎn)品產(chǎn)地： 臺灣
品牌商標(biāo)： Abnova
更新時間： null
使用范圍：
亞諾法生技股份有限公司（Abnova)
- 聯(lián)系人 :
- 地址 : 臺灣臺北市內(nèi)湖區(qū)洲子街 108 號 9 樓
- 郵編 : 11493
- 所在區(qū)域 : 臺灣
- 電話 : +886-920**1152 點擊查看
- 傳真 : 點擊查看
- 郵箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against native ITGAM.
- Immunogen:
- Native purified ITGAM from human granulocytes.
- Host:
- Mouse
- Theoretical MW (kDa):
- 165-170
- Reactivity:
- Human
- Specificity:
- This antibody recognizes CD11b antigen (Mac-1 alpha), a 165-170 KDa type I transmembrane protein mainly expressed on monocytes, granulocytes and NK-cells. The CD11b mediates neutrophil and monocyte interactions with stimulated endothelium.
- Form:
- Liquid
- Conjugation:
- PE
- Isotype:
- IgG2a
- Storage Buffer:
- In PBS (0.2% BSA, 15 mM sodium azide)
- Storage Instruction:
- Store in the dark at 4°C. Do not freeze.
Avoid prolonged exposure to light.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Flow Cytometry (20 ul in human blood cells 100 ul in whole blood or 106 cells in a suspension)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- CD11b of Ovis canadensis and Ovis aries: molecular cloning and characterization.
Lawrence PK, Srikumaran S.Vet Immunol Immunopathol. 2007 Oct 15;119(3-4):287-98. Epub 2007 Jun 3.
- 2.
- Effects of beta-glucans on the immune system.
Akramiene D, Kondrotas A, Didziapetriene J, Kevelaitis E.Medicina (Kaunas). 2007;43(8):597-606.
- 3.
- Sequential binding of CD11a/CD18 and CD11b/CD18 defines neutrophil capture and stable adhesion to intercellular adhesion molecule-1.
Hentzen ER, Neelamegham S, Kansas GS, Benanti JA, McIntire LV, Smith CW, Simon SI.Blood. 2000 Feb 1;95(3):911-20.
- Application Image
- Flow Cytometry
- Entrez GeneID:
- 3684
- Gene Name:
- ITGAM
- Gene Alias:
- CD11B,CR3A,MAC-1,MAC1A,MGC117044,MO1A,SLEB6
- Gene Description:
- integrin, alpha M (complement component 3 receptor 3 subunit)
- Omim ID:
- 120980
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
- Other Designations:
- antigen CD11b (p170),complement component receptor 3, alpha,integrin alpha M,macrophage antigen alpha polypeptide,neutrophil adherence receptor alpha-M subunit
- Related Disease
- Autoimmune Diseases
- Cardiovascular Diseases
- Crohn's disease
- Diabetes Mellitus, Type 1
- Diabetes Mellitus, Type 2
- Disease Susceptibility
- Edema
- Genetic Predisposition to Disease
- Helicobacter Infections
- Lupus Erythematosus, Discoid
- Lupus Erythematosus, Systemic
- Lupus Nephritis
- Macular Degeneration
- Nephritis
- Stomach Ulcer