Binimetinib 606143-89-9
產品名稱： Binimetinib 606143-89-9
英文名稱： Binimetinib
產品編號： 606143-89-9
產品價格： 0
產品產地： 國外
品牌商標： MEDKOO
更新時間： null
使用范圍： null
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Description:?Binimetinib, also known as MEK162 (ARRY-162), is an oral, highly selective MEK inhibitor. In preclinical studies, MEK162 showed significant antitumor activities in cell lines and animal models. MEK162 is the first targeted therapy to show activity in patients with NRAS -mutated melanoma and might offer a new option for a cancer with few effective treatments.
CAS#: 606143-89-9
Chemical Formula: C17H15BrF2N4O3
Exact Mass: 440.02956
Molecular Weight: 441.22681
Elemental Analysis: C, 46.28; H, 3.43; Br, 18.11; F, 8.61; N, 12.70; O, 10.88
Synonym:?MEK162; MEK-162; MEK 162; ARRY162; ARRY-162; ARRY 162; ARRY438162, Binimetinib; Brand name: Mektovi.
IUPAC/Chemical Name:?5-((4-bromo-2-fluorophenyl)amino)-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzo[d]imidazole-6-carboxamide.
InChi Key:?ACWZRVQXLIRSDF-UHFFFAOYSA-N
InChi Code:?InChI=1S/C17H15BrF2N4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26)
SMILES Code:?O=C(C1=C(NC2=CC=C(Br)C=C2F)C(F)=C3N=CN(C)C3=C1)NOCCO
Appearance:?Solid powder
Purity:?>98% (or refer to the Certificate of Analysis)
Shipping Condition:?Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition:?Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility:?Soluble in DMSO
Shelf Life:?>2 years if stored properly
Drug Formulation:?This drug may be formulated in DMSO
Stock Solution Storage:?0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code:?2934.99.9001