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Other Recombinant Proteins
Recombinant Human BD-3





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		Synonyms :
beta-defensin-3



		Description :
Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system.  The α-defensins are distinguished from the β-defensins by the pairing of their three disulfide bonds.  To date, four human β-defensins have been identified; BD-1, BD-2, BD-3 and BD-4.  β-defensins are expressed on some leukocytes and at epithelial surfaces.  In addition to their direct antimicrobial activities, they are chemoattractant towards immature dendritic cells and memory T cells.  The β-defensin proteins are expressed as the C-terminal portion of precursors and are released by proteolytic cleavage of a signal sequence and, in the case of BD-1 (36 a.a.), a propeptide region.  β-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds.  β-Defensins are 3-5 kDa peptides ranging in size from 33-47 amino acid residues.  Recombinant Human BD-3 is a 5.1 kDa protein containing 45 amino acid residues.



		Catalog #:
300-52



		Source :
E.coli



		Purity :
Greater then 98% by SDS-PAGE gel and HPLC analyses.



		Endotoxin Level :
Endotoxin level is less than 0.1 ng per μg (1EU/μg).



		Biological Activity :
Exhibits antimicrobial activity against gram-positive bacteria S. aureus and gram-negative P. aeruginosa and E.coli.


Selected References :
Selected List of References Citing This PeproTech Product



                AA Sequence :
GIINTLQKYY CRVRGGRCAV LSCLPKEEQI GKCSTRGRKC CRRKK 



		PubMed Link :
beta-defensin-3+AND+human


Country of Origin :
USA
















        Size A
5μg
$80?
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        Size B
20μg
$195?
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        Size C
1mg
$3000?
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Special 
                    Sizes: 
 Many products can be ordered in custom sizes. Please click here to contact Peprotech with your request.





Usage:
For Research Use Only.  Not for use in diagnostic or therapeutic procedures.