TPMT monoclonal antibody (M02), clone 1D4
產品名稱： TPMT monoclonal antibody (M02), clone 1D4
英文名稱： TPMT monoclonal antibody (M02), clone 1D4
產品編號： H00007172-M02
產品價格： null
產品產地： 臺灣
品牌商標： Abnova
更新時間： null
使用范圍：
亞諾法生技股份有限公司（Abnova)
- 聯系人 :
- 地址 : 臺灣臺北市內湖區洲子街 108 號 9 樓
- 郵編 : 11493
- 所在區域 : 臺灣
- 電話 : +886-920**1152 點擊查看
- 傳真 : 點擊查看
- 郵箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against a full length recombinant TPMT.
- Immunogen:
- TPMT (AAH05339, 1 a.a. ~ 245 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
- Sequence:
- MDGTRTSLDIEEYSDTEVQKNQVLTLEEWQDKWVNGKTAFHQEQGHQLLKKHLDTFLKGKSGLRVFFPLCGKAVEMKWFADRGHSVVGVEISELGIQEFFTEQNLSYSEEPITEIPGTKVFKSSSGNISLYCCSIFDLPRTNIGKFDMIWDRGALVAINPGDRKCYADTMFSLLGKKFQYLLCVLSYDPTKHPGPPFYVPHAEIERLFGKICNIRRLEKVDAFEERHKSWGIDCLFEKLYLLTEK
- Host:
- Mouse
- Reactivity:
- Human
- Isotype:
- IgG1 Kappa
- Storage Buffer:
- In 1x PBS, pH 7.2
- Storage Instruction:
- Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (52.69 KDa) .
- MSDS:
Download
- Applications
- Western Blot (Transfected lysate)
- Western Blot analysis of TPMT expression in transfected 293T cell line by TPMT monoclonal antibody (M02), clone 1D4.
Lane 1: TPMT transfected lysate(28.2 KDa).
Lane 2: Non-transfected lysate. - Protocol Download
- Western Blot (Recombinant protein)
- Protocol Download
- Immunofluorescence
enlarge this image- Immunofluorescence of monoclonal antibody to TPMT on HeLa cell. [antibody concentration 10 ug/ml]
- Protocol Download
- Sandwich ELISA (Recombinant protein)
- Detection limit for recombinant GST tagged TPMT is approximately 1ng/ml as a capture antibody.
- Protocol Download
- Entrez GeneID:
- 7172
- GeneBank Accession#:
- BC005339
- Protein Accession#:
- AAH05339
- Gene Name:
- TPMT
- Gene Alias:
- -
- Gene Description:
- thiopurine S-methyltransferase
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals. A pseudogene for this locus is located on chromosome 18q. [provided by RefSeq
- Other Designations:
- OTTHUMP00000016076,S-adenosyl-L-methionine:thiopurine S-methyltransferase,thiopurine methyltransferase
- Gene Pathway
- Related Disease
- Acute Disease
- Agranulocytosis
- Alopecia
- Arthritis, Rheumatoid
- Autoimmune Diseases
- Bone Marrow Diseases
- Brain Neoplasms
- Cardiovascular Diseases
- Colitis, Ulcerative
- Colorectal Neoplasms
- Communicable Diseases
- Crohn Disease
- Crohn's disease
- Diabetes Mellitus, Type 2
- DNA Damage
- Drug Toxicity
- Edema
- Gastrointestinal Diseases
- Genetic Predisposition to Disease