FAM59A Antibody
產(chǎn)品名稱： FAM59A Antibody
英文名稱： FAM59A Antibody
產(chǎn)品編號： 254171
產(chǎn)品價格： null
產(chǎn)品產(chǎn)地： 美國
品牌商標(biāo)： Abbiotec
更新時間： null
使用范圍： E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:00-1:500
深圳市豪地華拓生物科技有限公司
- 聯(lián)系人 :
- 地址 : 深圳市南山創(chuàng)業(yè)路中興城5棟518
- 郵編 : 518054
- 所在區(qū)域 : 廣東
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- 郵箱 : order@otwobiotech.com
FAM59A, also known as GAREM, was initially identified through a mass spectroscoptic method that measures different phosphotyrosine states of proteins in response to different cell stimuli. FAM59A is a downstream molecule in the EGF signaling pathway that is tyrosine-phosphorylated, and this phosphorylation is needed for the binding of Grb2, an adaptor protein crucial to the transduction of growth signals from the plasma membrane to the nucleus. ERK activation in response to EGF stimulation is regulated by FAM59A in COS-7 and HeLa cells, and the overexpression of FAM59A stimulated cell proliferation and colony formation in soft agar, suggesting that FAM59A might be a critical protein with roles in ligand-mediated signaling pathway of the EGF receptor and the tumorigenesis of cells.