Anti-ADAM17 Polyclonal Antibody
產品名稱： Anti-ADAM17 Polyclonal Antibody
英文名稱： A disintegrin and metalloproteinase domain 17;ADAM 17;ADAM metallopeptidase domain 17;ADAM17 protein;CD 156b;CD156b
產品編號： K009631P
產品價格： null
產品產地： 北京
品牌商標：
更新時間： 2026-07-02T10:39:01
使用范圍： WB ELISA IHC-P IHC-F Flow-Cyt IF
北京索萊寶科技有限公司
- 聯系人 : 索萊寶-龔思雨
- 地址 : 北京市北京經濟技術開發區環科中路16號26幢3層301
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- 所在區域 : 北京
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- 郵箱 : 3193328036@qq.com
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Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form (PubMed:9034191). Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (PubMed:20592283). Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein (PubMed:12441351). Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT) (PubMed:24226769). Plays a role in the proteolytic processing of ACE2 (PubMed:24227843). Plays a role in hemostasis through shedding of GP1BA, the platelet glycoprotein Ib alpha chain (By similarity). Mediates the proteolytic cleavage of LAG3, leading to release the secreted form of LAG3 (By similarity). Mediates the proteolytic cleavage of IL6R, leading to the release of secreted form of IL6R (PubMed:26876177, PubMed:28060820).